The correcting effects of dihydroquercetin in cerebral ischemia-reperfusion injury

   


1. Grodno State Medical University
Type: Experimental study
DOI: 10.18097/PBMC20146006643      UDK: 616.831–005.4–085:615.272      PubMed Id: 25552503
Year: 2014 vol: 60  issue:6  pages: 643-650
Abstract: The dynamics of changes in the mitochondrial respiratory function, changes in the parameters of carbohydrate metabolism and some parameters of oxidative stress in the brain tissue have been investigated under conditions of ischemia-reperfusion and administration of dihydroquercetin. Dihydroquercetin (65 mg/kg) was administered per os 1 h before modeling of ischemia-reperfusion. Studies were carried 1 h after reperfusion. It was found that administration of dihydroquercetin caused a corrective effect to impairments of the respiratory function of mitochondria, indicators of carbohydrate metabolism and parameters of oxidative stress induced by ischemia-reperfusion.
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Reference: Maksimovich N.Ye., Dremza I.K., Troyan E.I., Maksimovich Ya.N., Borodinskii A.N., The correcting effects of dihydroquercetin in cerebral ischemia-reperfusion injury, Biomeditsinskaya khimiya, 2014, vol: 60(6), 643-650.
This paper is also available as the English translation:10.1134/S1990750814020073
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