Membrane type 1 matrix metalloproteinase (MT1-MMP) and the regulators of its activity as invasive factors in squamous cell cervical carcinomas

   


1. Orekhovich Institute of Biomedical Chemistry
Type: Clinical study
DOI: 10.18097/PBMC20146006683      UDK: 577.3.4*24'142      PubMed Id: 25552509
Year: 2014 vol: 60  issue:6  pages: 683-688
Abstract: Membrane type 1 matrix metalloproteinase (MT1MMP) is one of matrix metalloproteinases (MMP), which play а key role in tumor invasion and metastasis. The aim of this study was to elucidate the peculiarities of expression of MT1MMP and endogenous regulators of its activity: the activator – furin and the inhibitor – TIMP-2, as invasive factors of squamous cell cervical carcinomas (SCC). The study was carried out using 11 specimens of SCC and 11 specimens of morphologically normal tissue adjacent to the tumor. It was shown that the increase of MT1-MMP and furin expression and low of TIMP-2 expression makes the main contribution to the destructive (invasive) potential of SCC. Moreover, substantial expression of MT1-MMP was registered in the specimens of morphologically normal adjoining to tumor tissue. This expression was found to make an additional contribution to the destructive potential of the cervical tumor.
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Reference: Timoshenko O.S., Gureeva T.A., Kugaevskaya E.V., Solovyeva N.I., Membrane type 1 matrix metalloproteinase (MT1-MMP) and the regulators of its activity as invasive factors in squamous cell cervical carcinomas, Biomeditsinskaya khimiya, 2014, vol: 60(6), 683-688.
This paper is also available as the English translation:10.1134/S1990750815040071
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