Oxidative stress and its effect on cells functional activity of Alzheimer's disease

   


1. St. Peterburg Bekhterev Psychoneurological Research Institute, Saint Petersburg, Russia
Type: Review
DOI: 10.18097/PBMC20156101057      UDK: 577.344      PubMed Id: 25762599
Year: 2015 vol: 61  issue:1  pages: 57-69
Abstract: The paper summarizes literature data on the importance of oxidative stress as one of the pathogenetic mechanisms in Alzheimer's disease. The paper describes the main specific and nonspecific ways of reactive oxygen species generation in the course of the disease development. The effect of reactive oxygen species generated by the functional activity of cells, i.e. apoptosis and mitotic cycle, is shown. The role of the regulatory system of nodal cells is performed by phosphorylation/dephosphorylation process which is associated with intense phosphorylation of tau protein and mitosis-specific proteins. In Alzheimer's disease, the regulating function of peptidyl-prolyl isomerases in particular of Pin1 associated with maintaining a balanced state of phosphorylation/dephosphorylation processes is disturbed. Taking into consideration the multifactorial impairment of the cell cycle control, this process should be considered from the standpoint of the general state of metabolic processes, and oxidative stress has one of the key positions in aging.
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Reference: Dubinina E.E., Schedrina L.V., Neznanov N.G., Zalutskaya N.M., Zakharchenko D.V., Oxidative stress and its effect on cells functional activity of Alzheimer's disease, Biomeditsinskaya khimiya, 2015, vol: 61(1), 57-69.
This paper is also available as the English translation:10.1134/S1990750814030044
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