Insulin resistance pathogenesis in metabolic obesity

Litvinova L.S.; Kirienkova E.V.; Mazunin I.O.; Vasilenko M.A.; Fattakhov N.S.

doi:10.18097/PBMC20156101070

Insulin resistance pathogenesis in metabolic obesity

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1. Immanuel Kant Baltic Federal University, Kaliningrad, Russia

Type: Review

DOI: 10.18097/PBMC20156101070 UDK: 612.346:612.43:612.349.8 PubMed Id: 25762600

Year: 2015 vol: 61 issue:1 pages: 70-82

Abstract: In this review we discuss the molecular mechanisms of insulin resistance concomitant with metabolic inflammation. We also analyze the world results of experimental and clinical studies which aimed at identifying the molecular targets for the development of new prevention and treatment of insulin resistance.

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Reference: Litvinova L.S., Kirienkova E.V., Mazunin I.O., Vasilenko M.A., Fattakhov N.S., Insulin resistance pathogenesis in metabolic obesity, Biomeditsinskaya khimiya, 2015, vol: 61(1), 70-82.

This paper is also available as the English translation:10.1134/S1990750814030093

References

1. Hirabara S.M., Gorjão R., Vinolo M.A., Rodrigues A.C., Nachbar R.T., Curi R. (2012) J. Biomed. Biotechnol., 2012, ID 379024. Scholar google search
2. Tron'ko N.D., Kovzun E.I., Pushkarev V.M. (2012) “ZH. NАMN Ukraїni” 18(4), 430-439. Scholar google search
3. Burks D.J., White M.F. (2001) Diabetes, 50, 140-145. CrossRef Scholar google search
4. Durmuş Tekir S., Ümit P., Toku E.A., Ülgen K.O. (2010) J. Biomed. Biotechnol., 2010, ID 690925, 7 pages. Scholar google search
5. Thirone A.C., Huang C., Klip A. (2006) Trends Endocrinol. Metab., 17, 72-78. CrossRef Scholar google search
6. Thong F.S.L., Dugani C.B., Klip A. (2005) Physiology, 4, 271-284. CrossRef Scholar google search
7. Sharma M.D., Garber A.J., Farmer J.A. (2008) Endocr. Pract., 14, 373–380. CrossRef Scholar google search
8. Mitra P., Zheng X., Czech M.P. (2004) J. Biol. Chem., 279, 37431–37435. CrossRef Scholar google search
9. Chang L., Chiang S., Saltiel A.R. (2004) Mol. Med., 10(7-12), 65–71. Scholar google search
10. Skolnik E.Y., Batzer A., Li N., Lee C.H., Lowenstein E., Mohammadi M., Margolis B., Schlessinger J. (1993) Science, 260(5116), 1953–1955. CrossRef Scholar google search
11. Gureasko J., Galush W.J., Boykevisch S., Sondermann H., Bar-Sagi D., Groves J.T., Kuriyan J. (2008) Nat. Struct. Mol. Biol., 15, 452–461. CrossRef Scholar google search
12. Combettes-Souverain M., Issad T. (1998) Diabetes Metab., 24, 477–489. Scholar google search
13. Somwar R., Kim D.Y., Sweeney G., Huang C., Niu W., Lador C., Ramlal T., Klip A. (2001) Biochem. J., 359, 639–649. CrossRef Scholar google search
14. Rains J.L., Jain S.K. (2011) Free Radic. Biol. Med., 50, 567–575. CrossRef Scholar google search
15. Henriksen E.J., Diamond-Stanic M.K., Marchionne E.M. (2011) Free Radic. Biol. Med., 51,993–999. CrossRef Scholar google search
16. Kontrogianni-Konstantopoulos A., Benian G.,Granzier H. (2012) J. Biomed. Biotechnol., 2012, ID 930836. Scholar google search
17. Martins A.R., Nachbar R.T., Gorjao R.,Vinolo M.A., Festuccia W.T., Lambertucci R.H., Cury-Boaventura M.F., Silveira L.R., Curi R.,Hirabara S.M. (2012) Lipids Health Dis., 11, 30. CrossRef Scholar google search
18. Newsholme P., Haber E.P., Hirabara S.M.,Rebelato E.L., Procopio J., Morgan D.,Oliveira-Emilio H.C., Carpinelli A.R., Curi R. (2007)J. Physiol., 583, 9–24. CrossRef Scholar google search
19. Brehm A., Krssak M., Schmid A.I., Nowotny P., Waldhäusl W., Roden M. (2006) Diabetes, 55, 136–140. CrossRef Scholar google search
20. Lenoir O., Flosseau K., Ma F.X., Blondeau B., Mai A., Bassel-Duby R., Ravassard P., Olson E.N., Haumaitre C., Scharfmann R. (2011) Diabetes, 60, 2861–2871. CrossRef Scholar google search
21. Rajendran R., Garva R., Krstic-Demonacos M., Demonacos C. (2011) J. Biomed. Biotechnol., 2011, ID 368276. Scholar google search
22. Bashan N., Kovsan J., Kachko I., Ovadia H., Rudich A. (2009) Physiol. Rev., 89, 27-71. CrossRef Scholar google search
23. Zhang L., Haraguchi S., Koda T., Hashimoto K., Nakagawara A. (2011) J. Biomed. Biotechnol., 2011, ID 831092. Scholar google search
24. Pankratova M.А., Pirozhkov S.V., Balabolkin M.I., Litvitskij P.F. (2006) Sakharnyj diabet, №2, 12-15 Scholar google search
25. Laybutt D.R., Kaneto H., Hasenkamp W., Grey S., Jonas J.C., Sgroi D.C., Groff A., Ferran C., Bonner-Weir S., Sharma A., Weir G.C. (2002) Diabetes, 51, 413-423. CrossRef Scholar google search
26. Shvarts V. (2009) Terapevticheskij arkhiv, №10, 74-80. Scholar google search
27. Fernandez-Real J.M., Ricart W. (2003) Endocr. Rev., 24, 278–301. CrossRef Scholar google search
28. Shvarts V. (2009) Kardiologiya, №12, 80–86. Scholar google search
29. Medzhitov R. (2008). Nature, 454(7203), 428–435. CrossRef Scholar google search
30. Mathis D. (2013) Cell. Metab., 17, 851-859. CrossRef Scholar google search
31. Kulikov D.I., Vasilenko M.А., Kirienkova E.V., Mazunin I.O., Zatolokin P.А., Litvinova L.S. (2013) Vestnik BFU im. I. Kanta, 4, 51-56. Scholar google search
32. Hotamisligil G.S. (2006) Nature, 444(7121), 860–867. CrossRef Scholar google search
33. Fuentes E., Fuentes F., Vilahur G., Lina Badimon L., Palomo I. (2013) Mediators Inflamm., 2013, ID 136584. Scholar google search
34. Ellingsgaard H., Hauselmann I., Schuler B., Habib A.M., Baggio L.L., Meier D.T., Eppler E., Bouzakri K., Wueest S., Muller Y.D., Hansen A.M., Reinecke M., Konrad D., Gassmann M., Reimann F., Halban P.A., Gromada J., Drucker D.J., Gribble F.M., Ehses J.A., Donath M.Y. (2011) Nat. Med., 17, 1481–1489. CrossRef Scholar google search
35. Donath M.Y., Dalmas É., Sauter N.S., Böni-Schnetzler M. (2013) Cell Metab., 17, 860-872. CrossRef Scholar google search
36. Turu M.M., Slevin M., Matou S., West D., Rodríguez C., Luque A., Grau-Olivares M., Badimon L., Martinez-Gonzalez J., Krupinski J. (2008) BMC Cell. Biol., 9, 47. CrossRef Scholar google search
37. Kirienkova E.V., Litvinova L.S., Seledtsov V.I., Zatolokin P.А., Аksenova N.N. (2012) Klin. labor. diagn., №12, 3-5. Scholar google search
38. Litvinova L.S., Zatolokin P.А., Poznyak E.V., Seledtsova I.А., Kirienkova E.V., Seledtsov V.I. (2011) Аnnaly khirurgii, prilozhenie 1, 39-40. Scholar google search
39. Sun K., Kusminski C.M., Scherer P.E. (2011) J. Clin. Invest., 121(6), 2094–2101. CrossRef Scholar google search
40. Aderem A., Ulevitch R.J. (2000) Nature, 406(6797), 782–787. CrossRef Scholar google search
41. Dasu M.R., Devaraj S., Park S., Jialal I. (2010) Diabetes Care, 33(4), 861–868. CrossRef Scholar google search
42. Kim H.S., Han M.S., Chung K.W., Kim S., Kim E., Kim M.J., Jang E., Lee H.A., Youn J., Akira S., Lee M.S. (2007) Immunity, 27(2), 321–333. CrossRef Scholar google search
43. Kopp A., Buechler C., Bala M., Neumeier M., Schölmerich J., Schäffler A. (2010) Endocrinology, 151, 1097–1108. CrossRef Scholar google search
44. Haversen L., Danielsson K.N., Fogelstrand L., Wiklund O. (2009) Atherosclerosis, 202, 382–393. CrossRef Scholar google search
45. Wen H., Gris D., Lei Y., Jha S., Zhang L., Huang M.T., Brickey W.J. Ting J.P. (2011) Nat. Immunol., 12, 408–415. CrossRef Scholar google search
46. Rydén M., Dicker A., Van Harmelen V., Hauner H., Brunnberg M., Perbeck L., Lonnqvist F., Arner P. (2002) J. Biol. Chem., 277, 1085-1091. CrossRef Scholar google search
47. Ye J., Gao Z., Yin J., He Q. (2007) Am. J. Physiol. Endocrinol. Metab., 293, 1118-1128. CrossRef Scholar google search
48. Davis H.M., Carpenter D.C., Stahl J.M., Zhang W., Hynicka W.P., Griswold D.E. (2000) J. Immunol. Methods, 240, 125–132. CrossRef Scholar google search
49. Deopurkar R., Ghanim H., Friedman J., Abuaysheh S., Sia C.L., Mohanty P., Viswanathan P., Chaudhuri A., Dandona P. (2010) Diabetes Care, 33(5), 991–997. CrossRef Scholar google search
50. Yan S.F., Ramasamy R., Schmidt A.M. (2009) J. Mo.l Med. (Berl.), 87(3), 235–247. CrossRef Scholar google search
51. Zhou R., Tardivel A., Thorens B., Choi I., Tschopp J. (2010) Nat. Immunol., 11, 136–140. CrossRef Scholar google search
52. Böni-Schnetzler M., Boller S., Debray S., Bouzakri K., Meier D.T., Prazak R., Kerr-Conte J., Pattou F., Ehses J.A., Schuit F.C., Donath M.Y. (2009) Endocrinology, 150, 5218-5229. CrossRef Scholar google search
53. Peppa M., Koliaki C., Nikolopoulos P., Raptis S.A. (2010) J. Biomed. Biotechnol., 2010, ID 527850. Scholar google search
54. Shvarts V. (2009) Problemy ehndokrinologii, 55(1), 38-44. Scholar google search
55. Mothe-Satney I., Filloux C., Amghar H., Pons C., Bourlier V., Galitzky J., Grimaldi P.A., Féral C.C., Bouloumié A., Van Obberghen E., Neels J.G. (2012) Diabetes, 61(9), 2311–2319. CrossRef Scholar google search
56. Kurokaw J., Nagano H., Ohara O., Kubota N., Kadowaki T., Arai S., Miyazaki T. (2011) Proc. Natl. Acad. Sci.USA., 108, 12072–12077. CrossRef Scholar google search
57. Yang H., Youm Y.H., Vandanmagsar B., Ravussin A., Gimble J.M., Greenway F., Stephens J.M., Mynatt R.L., Dixit V.D. (2010) J. Immunol., 185, 1836-1845. CrossRef Scholar google search
58. Feuerer M., Herrero L., Cipolletta D., Naaz A., Wong J., Nayer A., Lee J., Goldfine A.B., Benoist C.,Shoelson S., Mathis D. (2009) Nat. Med., 15, 930–939. CrossRef Scholar google search
59. Rocha V.Z., Folco E.J., Sukhova G., Shimizu K., Gotsman I., Vernon A.H., Libby P. (2008) Circ. Res., 103, 467–476. CrossRef Scholar google search
60. Bertola A., Ciucci T., Rousseau D., Bourlier V., Duffaut C., Bonnafous S., Blin-Wakkach C., Rodolphe A.A., Gugenheim I.J., Tran A.B., Wakkach P.G. (2012) Diabetes, 61, 2238–2247. CrossRef Scholar google search
61. Mandal P., Pratt B.T., Barnes M., McMullen M.R., Nagy L.E. (2011) J. Biol. Chem., 286, 13460–13469. CrossRef Scholar google search
62. Zamboni M., Di Francesco V., Garbin U., Fratta Pasini A., Mazzali G., Stranieri C., Zoico E., Fantin F., Bosello O., Cominacini L. (2007) Int. J. Obes. (Lond.), 31, 1104-1109. CrossRef Scholar google search
63. Litvinova L.S., Kirienkova E.V., Аksenova N.N., Zatolokin P.А., Gazatova N.D. (2012) Byulleten' SibGMU, 3, 53-58. Scholar google search
64. Litvinova L.S., Kirienkova E.V., Gazatova N.D., Zatolokin P.А., Vasilenko M.А., Simbirtsev А.S., Аksenova N.N. (2013) Tsitokiny i vospalenie, 12(3), 62-67. Scholar google search
65. Ofei F., Hurel S., Newkirk J., Sopwith M., Taylor R. (1996) Diabetes, 45, 881–885. CrossRef Scholar google search
66. Gonzalez-Gay M.A., De Matias J.M., Gonzalez-Juanatey C., Garcia-Porrua C., Sanchez-Andrade A., Martin J., Llorca J. (2006) Clin. Exp. Rheumatol., 24, 83-86. Scholar google search
67. Gonzalez-Gay M.A., Gonzalez-Juanatey C., Vazquez-Rodriguez T.R., Miranda-Filloy J.A., Llorca J. (2010)Ann. N-Y Acad. Sci., 1193, 153-159. CrossRef Scholar google search
68. Stagakis I., Bertsias G., Karvounaris S., Kavousanaki M., Virla D., Raptopoulou A., Kardassis D., Boumpas D.T., Sidiropoulos P.I. (2012) Arthritis Res. Ther., 14, R 141. Scholar google search
69. Ridker P.M., Thuren T., Zalewski A., Libby P. (2011) Am. Heart J., 162(4), 597–605. CrossRef Scholar google search
70. Cho H., Black S.C., Looper D., Shi M., Kelly-Sullivan D., Timofeevski S., Siegel K., Yu X.H., McDonnell S.R., Chen P., Yie J., Kathleen M.O., Fraser J., Briscoe C.P. (2008) Am. J. Physiol. Endocrinol. Metab., 295, 1142–1151. CrossRef Scholar google search
71. Stebbins J.L., De S.K., Machleidt T., Becattini B., Vazquez J., Kuntzen C., Chen L.H., Cellitti J.F., Riel-Mehan M., Emdadi A., Solinas G., Karin M., Pellecchia M. (2008) Proc. Natl. Acad. Sci. USA, 105, 16809-16813. CrossRef Scholar google search
72. Ramos-Zavala M.G., González-Ortiz M., Martínez-Abundis E., Robles-Cervantes J.A., González-Lуpez R., Santiago-Hernández N.J. (2011) Diabetes Care, 34, 1591–1594. Scholar google search
73. Pavlatou M.G., Mastorakos G., Margeli A., Kouskouni E., Tentolouris N., Katsilambros N., Chrousos G.P., Papassotiriou I. (2011) Eur. J. Clin. Invest., 41, 652–658. CrossRef Scholar google search
74. Fujisaka S., Usui I., Kanatani Y., Ikutani M., Takasaki I., Tsuneyama K., Tabuchi Y., Bukhari A., Yamazaki Y., Suzuki H., Senda S., Aminuddin A., Nagai Y., Takatsu K., Kobayashi M., Tobe K. (2011) Endocrinology, 152, 1789–1799. CrossRef Scholar google search
75. Van der Zijl N.J., Moors C.C., Goossens G.H., Blaak E.E., Diamant M. (2012) Diabetes Obes. Metab., 14, 586–595. CrossRef Scholar google search
76. Yu A.M. (2009) Expert Opin. Drug. Metab. Toxicol., 5, 1513–1528. CrossRef Scholar google search
77. Garcia-Guerra L., Nieto-Vazquez I., Vila-Bedmar R., Jurado-Pueyo M., Zalba G., Dнez J., Murga C., Fernández-Veled S., Mayor F. Jr., Lorenzo M. (2010) Diabetes, 59, 2407-2417. CrossRef Scholar google search
78. Luan B., Zhao J., Wu H., Duan B., Shu G.W., Wang X.Y., Li D., Jia W., Kang J., Pei G. (2009) Nature, 457, 1146–1150. CrossRef Scholar google search
79. Hotamisligil G.S., Shargill N.S., Spiegelman B.M. (1993) Science, 259(5091), 87–91. CrossRef Scholar google search
80. Feng X., Wang W., Liu J., Liu Y. (2011) Mol. Biol. Rep., 38, 2517–2528. CrossRef Scholar google search
81. Mayor F. Jr., Lucas E., Jurado-Pueyo M., Garcia-Guerra L., Nieto-Vazquez I., Vila-Bedmar R., Fernández-Veledo S., Murga C. (2011)Arch. Physiol. Biochem., 117, 125–130. CrossRef Scholar google search
82. Vinolo M.A., Hirabara S.M., Curi R. (2012) Curr. Opin. Clin. Nutr. Metab. Care, 15, 112–116. CrossRef Scholar google search
83. Tuo Y., Feng D.D., Wang D.-F., Sun J., Li S.-B., Chen C. (2012) Clin. Exp. Pharmacol. Physiol., 39, 423–428. CrossRef Scholar google search
84. Chu Z.L., Jones R.M., He H., Carroll C., Gutierrez V., Lucman A., Moloney M., Gao H., Mondala H., Bagnol D., Unett D., Liang Y., Demarest K., Semple G., Behan D.P., Leonard J. (2007) Endocrinology, 148, 2601–2609. Scholar google search
85. Edfalk S., Steneberg P., Edlund H. (2008) Diabetes, 57, 2280–2287. CrossRef Scholar google search
86. Hansen K.B., Rosenkilde M.M., Knop F.K., Wellner N., Diep T.A., Rehfeld J.F., Andersen U.B., Holst J.J., Hansen H.S. (2011) J. Clin. Endocrinol. Metab., 96, 1409–1417. CrossRef Scholar google search
87. Oh D.Y., Talukdar S., Bae E.J., Imamura T., Morinaga H., Fan W., Li P., Lu W.J., Watkins S.M., Olefsky J.M. (2010) Cell, 142, 687–698. CrossRef Scholar google search
88. Glodak M.A., Sengupta N., Zhang X., Seto E. (2005) Gene, 363, 15-23. CrossRef Scholar google search
89. Grabiec A.M., Tak P.P., Reedquist K.A. (2011) Crit. Rev. Immunol., 31, 233–263. CrossRef Scholar google search
90. Christensen D.P., Dahllöf M., Lundh M., Rasmussen D.N., Nielsen M.D., Billestrup N., Grunnet L.G., Mandrup-Poulsen T. (2011) Mol. Med., 17, 378–390. CrossRef Scholar google search
91. Lewis E.C., Blaabjerg L., Stшrling J., Ronn S.G., Mascagni P., Dinarello C.A., Mandrup-Poulsen T. (2011) Mol. Med., 17, 369–377. CrossRef Scholar google search
92. Winkler R., Benz V., Clemenz M., Bloch M., Foryst-Ludwig A., Wardat S., Witte N., Trappiel M., Namsolleck P., Mai K., Spranger J., Matthias G., Roloff T., Truee O., Kappert K., Schupp M., Matthias P., Kintscher U. (2012) Diabetes, 61, 513–523. CrossRef Scholar google search
93. Fuentes E., Guzmán-Jofre L., Moore-Carrasco R., Palomo I. (2013) Mol. Med. Rep., 8, 1611-1616. Scholar google search
94. Chiarelli F., Di Marzio D. (2008) Vasc. Health Risk. Manag., 4, 297–304. Scholar google search
95. Odegaard J.I., Ricardo-González R.R., Goforth M.H., Morel C.R., Subramanian V., Mukundan L., Red Eagle A., Vats D., Brombacher F., Ferrante A.W., Chawla A. (2007) Nature, 447(7148), 1116–1120. CrossRef Scholar google search
96. Cipolletta D., Feuerer M., Li A., Kamei N., Lee J., Shoelson S.E., Benoist C., Mathis D. (2012) Nature, 486(7404), 549–553. Scholar google search
97. Sugii S., Evans R.M. (2011) FEBS Letts., 585(13), 2121–2128. CrossRef Scholar google search
98. Serhan C.N., Hong S., Gronert K., Colgan S.P., Devchand P.R., Mirick G., Moussignac R.L. (2002) J. Exp. Med., 196, 1025–1037. CrossRef Scholar google search
99. Clish C.B., O’Brien J.A., Gronert K., Stahl G.L., Petasis N.A., Serhan C.N. (1999) Proc. Natl. Acad. Sci. USA, 96, 8247–8252. Scholar google search
100. Mukherjee P.K., Marcheselli V.L., Barreiro S., Hu J., Bok D., Bazan N.G. (2007) Proc. Natl. Acad. Sci. USA, 104, 13152–13157. CrossRef Scholar google search
101. Titos E., Rius B., González-Périz A., Lуpez-Vicario C., Morán-Salvador E., Martínez-Clemente M., Arroyo V., Clària J. (2011) J. Immunol., 187, 5408–5418. Scholar google search
102. González-Périz A., Horrillo R., Ferré N., Gronert K., Dong B., Morán-Salvador E., Titos E., Martínez-Clemente M., López-Parra M., Arroyo V., Clària J. (2009) FASEB J., 23, 1946–1957. CrossRef Scholar google search
103. White P.J., Arita M., Taguchi R., Kang J.X., Marette A. (2010) Diabetes, 59, 3066–3073. CrossRef Scholar google search
104. Horrillo R., González-Périz A., Martínez-Clemente M., López-Parra M., Ferré N., Titos E., Morán-Salvador E., Deulofeu R., Arroyo V., Clària J. (2010) J. Immunol., 184, 3978–3987. CrossRef Scholar google search
105. Hellmann J., Tang Y., Kosuri M., Bhatnagar A., Spite M. (2011) FASEB J., 25, 2399–2407. CrossRef Scholar google search
106. Yu C., Chen Y., Cline G.W., Zhang D., Zong H., Wang Y., Bergeron R., Kim J.K., Cushman S.W., Cooney G.J., Atcheson B., White M.F., Kraegen E.W., Shulman G.I. (2002) J. Biol. Chem., 277, 50230-50236. CrossRef Scholar google search
107. Underbayev C., Kasar S., Yuan Y., Raveche E. (2012) J. Biomed. Biotechnol., 2012, ID 758169. Scholar google search
108. Xie H., Lim B., Lodish H.F. (2009) Diabetes, 58, 1050–1057. CrossRef Scholar google search
109. Frost R-J.A., Olson E.N. (2011) Proc. Natl. Acad. Sci. USA, 108, 21075–21080. CrossRef Scholar google search
110. Foley N.H., O'Neill L.A. (2012) J. Leukoc. Biol., 92, 521–527. Scholar google search
111. Hennessy E.J., Sheedy F.J., Santamaria D., Barbacid M., O’Neill A.J. (2011) J. Biol. Chem., 286, 25531–25539. Scholar google search

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