Analysis of proteomic profile changes of zebrafish embryos during exposure to doxorubicin, built-in the phospholipid transport nanosystem

   


1. Institute of Biomedical Chemistry, Moscow, Russia
Type:
DOI: 10.18097/PBMC20156103350      UDK: 578.064      PubMed Id: 26215412
Year: 2015 vol: 61  issue:3  pages: 350-356
Abstract: The proteome profile of Danio rerio embryos grown in the medium containing doxorubicin, included in the phospholipid transport nanosystem (doxolip) has been investigated using combination of 1D-electrophoresis with subsequent MALDI-TOF-PMF mass spectrometry. Cultivation of growing of D. rerio embryos in the medium with doxolip caused a substantial increase in expression of the cytoskeletal proteins, a decrease in the number of nuclear proteins involved in DNA and RNA synthesis and disappearance of vitellogenin 2 in comparison with control (the cultivation medium containing the phospholipid transport nanosystem). Analysis of the proteomic profiles of doxolip-treated embryos suggests lower toxicity of doxorubicin incorporated in the phospholipid nanosystem.
Download PDF:
Reference: Samenkova N.F., Kisrieva Y.S., Petushkova N.A., Kuznetsova G.P., Larina O.V., Trifonova O.P., Karuzina I.I., Ipatova O.M., Lisitsa A.V., Analysis of proteomic profile changes of zebrafish embryos during exposure to doxorubicin, built-in the phospholipid transport nanosystem, Biomeditsinskaya khimiya, 2015, vol: 61(3), 350-356.
Bibliography
 2016(Vol:62)
 2015(Vol:61)
 2014(Vol:60)
 2013(Vol:59)
 2012(Vol:58)
 2011(Vol:57)
 2010(Vol:56)
 2009(Vol:55)
 2008(Vol:54)
 2007(Vol:53)
 2006(Vol:52)
 2005(Vol:51)
 2004(Vol:50)
 2003(Vol:49)