Effects of berberine on the recovery of rat liver xenobiotic-metabolizing enzymes after partial hepatectomy

   


1. Institute of Biochemistry of Biologically Active Compounds NASB
Type: Experimental study
DOI: 10.18097/PBMC20156103381      UDK: 615.362+577.158(611.36)      PubMed Id: 26215416
Year: 2015 vol: 61  issue:3  pages: 381-383
Abstract: We have studied the effect of berberine on the recovery processes of liver xenobiotic-metabolizing function during its compensatory growth after 70% partial hepatectomy. It was found the hepatic ability to metabolize foreign substances are not restored up to day 8. Administration of berberine (10 mg/kg intraperitoneally) for 6 days led to normalization of both cytochrome P450-dependent and flavin-containing monooxygenases. It is suggested that in the biotransformation of berberine involved not only cytochrome P450, but also flavin-containing monooxygenases.
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Reference: Zverinsky I.V., Zverinskaya H.G., Sutsko I.P., Telegin P.G., Shlyahtun A.G., Effects of berberine on the recovery of rat liver xenobiotic-metabolizing enzymes after partial hepatectomy, Biomeditsinskaya khimiya, 2015, vol: 61(3), 381-383.
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