Abstract: We have studied the effect of berberine on the recovery processes of liver xenobiotic-metabolizing function during its compensatory growth after 70% partial hepatectomy. It was found the hepatic ability to metabolize foreign substances are not restored up to day 8. Administration of berberine (10 mg/kg intraperitoneally) for 6 days led to normalization of both cytochrome P450-dependent and flavin-containing monooxygenases. It is suggested that in the biotransformation of berberine involved not only cytochrome P450, but also flavin-containing monooxygenases.
Reference: Zverinsky I.V., Zverinskaya H.G., Sutsko I.P., Telegin P.G., Shlyahtun A.G., Effects of berberine on the recovery of rat liver xenobiotic-metabolizing enzymes after partial hepatectomy, Biomeditsinskaya khimiya, 2015, vol:
1. Nagayoshi S., Kawashita Y., Eguchi S., Kamohara Y., Takatsuki M., Miyamoto S., Mochizuki S., Soyama A., Tokai H., Hidaka M., Tajima Y., Kanematsu T. (2008) World J. Gastroenterol., 41, 6355-6359. CrossRef Scholar google search