Biological activity of selenorganic compounds at heavy metal salts intoxication

   


1. Razumovskiy Saratov State Medical University, Saratov, Russia
Type: Review
DOI: 10.18097/PBMC20156104449      UDK: 615.099:546.817]:615.014.425:546.23]-092.9      PubMed Id: 26350735
Year: 2015 vol: 61  issue:4  pages: 449-461
Abstract: Possible mechanisms of the antitoxic action of organoselenium compounds in heavy metal poisoning have been considered. Heavy metal toxicity associated with intensification of free radical oxidation, suppression of the antioxidant system, damage to macromolecules, mitochondria and the genetic material can cause apoptotic cell death or the development of carcinogenesis. Organic selenium compounds are effective antioxidants during heavy metal poisoning; they exhibit higher bioavailability in mammals than inorganic ones and they are able to activate antioxidant defense, bind heavy metal ions and reactive oxygen species formed during metal-induced oxidative stress. One of promising organoselenium compounds is diacetophenonyl selenide (DAPS-25), which is characterized by antioxidant and antitoxic activity, under conditions including heavy metal intoxication
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Reference: Rusetskaya N.Y., Borodulin V.B., Biological activity of selenorganic compounds at heavy metal salts intoxication, Biomeditsinskaya khimiya, 2015, vol: 61(4), 449-461.
This paper is also available as the English translation:10.1134/S1990750815010072
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