Increased manganese superoxide dismutase and cyclin B1 expression in carnosine-induced inhibition of glioblastoma cell proliferation

   


1. Neurology Research Center, Moscow, Russia
2. Free Radical and Radiation Biology Division, Department of Radiation Oncology, University of Iowa, Iowa City, USA
Type: Experimental/clinical study
DOI: 10.18097/PBMC20156104510      UDK: 616-006      PubMed Id: 26350743
Year: 2015 vol: 61  issue:4  pages: 510-518
Abstract: Carnosine is an endogenous dipeptide with antiproliferative properties. Here we show that carnosine selectively inhibits proliferation of human glioblastoma cells (U-118-MG) compared to breast (MB231) and oral (Cal27 and FaDu) cancer cells. Carnosine-induced inhibition of U-118-MG proliferation is associated with a significant: decrease in cellular reactive oxygen species levels, increase in manganese superoxide dismutase (MnSOD) and increase in cyclin B1 expression resulting in G2-block. We conclude that the antiproliferative property of carnosine is due to its ability to enhance MnSOD and cyclin B1 expression. These results will be of significance to the potential application of carnosine in brain cancer therapy
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Reference: Rybakova Yu.S., Kalen A.L., Eckers J.C., Fedorova T.N., Goswami P.C., Sarsour E.H., Increased manganese superoxide dismutase and cyclin B1 expression in carnosine-induced inhibition of glioblastoma cell proliferation, Biomeditsinskaya khimiya, 2015, vol: 61(4), 510-518.
This paper is also available as the English translation:10.1134/S1990750815010096
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