Pharmacokinetic and analgesic properties of the injectable dosage form of a new imidazobenzimidazole derivative RU-1205 with kappa agonist activity

   


1. Volgograd State Medical University, Volgograd, Russia; Volgograd Medical Research Center, Volgograd, Russia
2. Volgograd State Medical University, Volgograd, Russia
3. Institute of Physical and Organic Chemistry, South Federal University, Rostov-on-Don, Russia
Type: Experimental study
DOI: 10.18097/PBMC20156105636      UDK: 615.3:616-073      PubMed Id: 26539873
Year: 2015 vol: 61  issue:5  pages: 636-639
Abstract: Pharmacokinetic properties of imidazobenzimidazole derivative compound RU-1205 were investigated after subcutaneous administration to rabbits as a substance and a dosage form (lyophilisates for injection) at a dose of 25 mg/kg. The lyophilisate was characterized by high values of the relative bioavailability. In tests, the “hot plate” and “vinegar cramps” the dosage form and the substance exhibited the same analgesic effect.
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Reference: Spasov A.A., Smirnova L.A., Grechko O.U., Raschenko A.I., Shtareva D.M., Anisimova V.A., Pharmacokinetic and analgesic properties of the injectable dosage form of a new imidazobenzimidazole derivative RU-1205 with kappa agonist activity, Biomeditsinskaya khimiya, 2015, vol: 61(5), 636-639.
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