1. Volgograd State Medical University, Volgograd, Russia; Volgograd Medical Research Center, Volgograd, Russia 2. Volgograd State Medical University, Volgograd, Russia 3. Institute of Physical and Organic Chemistry, South Federal University, Rostov-on-Don, Russia
Abstract: Pharmacokinetic properties of imidazobenzimidazole derivative compound RU-1205 were investigated after subcutaneous administration to rabbits as a substance and a dosage form (lyophilisates for injection) at a dose of 25 mg/kg. The lyophilisate was characterized by high values of the relative bioavailability. In tests, the “hot plate” and “vinegar cramps” the dosage form and the substance exhibited the same analgesic effect.
Reference: Spasov A.A., Smirnova L.A., Grechko O.U., Raschenko A.I., Shtareva D.M., Anisimova V.A., Pharmacokinetic and analgesic properties of the injectable dosage form of a new imidazobenzimidazole derivative RU-1205 with kappa agonist activity, Biomeditsinskaya khimiya, 2015, vol:
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