Potentiation of activation of soluble guanylate cyclase by YC-1, NO-donors and increase of the synergistic effect of YC-1 on NO-dependent activation of the enzyme by 1,2,3-triazolyl-1,2,5-oxadiazole derivatives

   


1. Institute of Biomedical Chemistry, Moscow, Russia
2. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, Russia
Type: Experimental study
DOI: 10.18097/PBMC20156106705      UDK: 613.632.615.36      PubMed Id: 26716741
Year: 2015 vol: 61  issue:6  pages: 705-711
Abstract: The influence of (1H-1,2,3-triazol-1-yl)-1,2,5-oxadiazole derivatives: 4-amino-3-(5-methyl-4- ethoxycarbonyl-(1H-1,2,3-triazol-1-yl)-1,2,5-oxadiazole (TF 4 CH 3 ) and 4,4’-bis(5-methel-4-ethoxycarbonyl-1H- 1,2,3-triazol-1-yl)-3,3’-azo-1,2,5-oxadiazole (2TF 4 CH 3 ) on stimulation of human platelet soluble guanylate cyclase by YC-1, NO-donors (sodium nitroprusside, SNP, and spermine NONO ) and on a synergistic increase of NO-dependent enzyme activation in the presence of YC-1 has been investigated. Both compounds increased guanylate cyclase activation by YC-1, potentiated guanylate cyclase stimulation by NO-donors and increased the synergistic effect of YC-1 on NO-dependent activation of soluble guanylate cyclase. The similarity in the properties of the examined TF 4 CH 3 and 2TF 4 CH 3 with that of YC-1 and the possible mechanism underlying the revealed properties of compounds used are discussed.
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Reference: Severina I.S., Pyatakova N.V., Shchegolev A.Yu., Rozhkov V.Yu., Batog L.V., Makhova N.N., Potentiation of activation of soluble guanylate cyclase by YC-1, NO-donors and increase of the synergistic effect of YC-1 on NO-dependent activation of the enzyme by 1,2,3-triazolyl-1,2,5-oxadiazole derivatives, Biomeditsinskaya khimiya, 2015, vol: 61(6), 705-711.
This paper is also available as the English translation:10.1134/S1990750814010132
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