Biological activity and mechanisms of therapeutic action of rosmarinic acid, luteolin and its sulphated derivatives

   


1. Elyakov Pacibic Institute of Bioorganic Chemistry, Far Eastern Branch, Russian Academy of Sciences, Vladivostok, Russia; Far Eastern Federal University, Vladivostok, Russia
2. Elyakov Pacibic Institute of Bioorganic Chemistry, Far Eastern Branch, Russian Academy of Sciences, Vladivostok, Russia
Type: Review
DOI: 10.18097/PBMC20166201022      UDK: 76.03.31, 616-092.9, 616-03, 616-091.8, 577.125.8, 57.017.3      PubMed Id: 26973183
Year: 2016 vol: 62  issue:1  pages: 22-30
Abstract: The review considers recent experimental studies of biological activity and mechanisms of therapeutic action of rosmarinic acid, luteolin and its sulfated derivatives in diseases associated with disorders of carbohydrate and lipid metabolism. Particular attention is focused on the results of studies showing a high therapeutic potential of these phenolic compounds in their prophylactic and therapeutic use at experimental modeling of type 2 diabetes and hyperlipidemia. Based on the analysis of our results and the literature data putative mechanisms of therapeutic action of rosmarinic acid, luteolin and its sulfated derivatives have been proposed.
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Reference: Popov A.M., Krivoshapko O.N., Klimovich A.A., Artyukov A.A., Biological activity and mechanisms of therapeutic action of rosmarinic acid, luteolin and its sulphated derivatives, Biomeditsinskaya khimiya, 2016, vol: 62(1), 22-30.
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