Urea formation in the after operational liver


1. Tambov Regional Hospital, Tambov region, S. Pokrovo-Prigorodnoe, Russia; Burdenko Voronezh State Medical Academy, Voronezh, Russia
Type: Experimental study
DOI: 10.18097/PBMC20166201079      UDK: 616.36-02-089      PubMed Id: 26973192
Year: 2016 vol: 62  issue:1  pages: 79-81
Abstract: The effect of resection of the left lobe of the liver (LR, 15-20% og the organ weight) on hepatic urea formation was investigated in 84 albino rats. The objects of study were the surgery left (LLP), inoperable middle (MLP) lobe of the liver, blood (aorta, v. hepatica, v. porta) and choledochal bile. They studied the urea content. Arginase activity was examined in liver homogenate. On the day 3 and day 7 after resection reduced arginase activity was detected. LR caused a decrease of urea in v. hepatica, but increased urea content in the arterial blood and v. porta. Increase in bile urea on day 7 it was replaced by a decrease observed on day 14 of the postsurgery period. The concentration of urea in the liver on the 3rd day after LR was below the norm, and on the 7th and 14th day was within it. The results indicate a violation of urea operated by hepatocytes of the liver and extrahepatic activation mechanisms of the formation of urea.
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Reference: Savilov P.N., Urea formation in the after operational liver, Biomeditsinskaya khimiya, 2016, vol: 62(1), 79-81.
This paper is also available as the English translation:10.1134/S1990750816030136