Effect of melatonin instillations on the clinical course of experimental uveitis and biochemical processes in tears and aqueous humor

   


1. Moscow Helmholtz Research Institute of Eye Diseases, Moscow, Russia
2. Moscow State University, Chemistry faculty, Moscow, Russia
Type: Experimental study
DOI: 10.18097/PBMC20166202164      UDK: 617.721-002:616-003.283/284+577.17.05      PubMed Id: 27143374
Year: 2016 vol: 62  issue:2  pages: 164-168
Abstract: Acute immunogenic uveitis was modeled in rabbits via the subcutaneous and intravitreal injections of normal horse serum. We studied the effect of instillations of 0.1% melatonin solution on the clinical course of uveitis and biochemical parameters of tear fluid and aqueous humor: antioxi-dant activity, protein concentration and a2-macroglobulin level. Melatonin instillations decreased clinical manifestations of uveitis. We found that the antioxidant activity in tears of the rabbits treated with melatonin was substantially higher and the a2-macroglobulin level lower than in untreated animals. Antioxidant activity in aqueous humor taken on day 10 of uveitis was also twice higher while protein and a2-macroglobulin levels were 1.5-2 times lower than in untreated animals. These data indicate that instillations of melatonin increase the local antioxidant activity and decrease the acuity of inflammation and permeability of hematoophthalmic barrier in uveitis
Download PDF:
Reference: Chesnokova N.B., Beznos O.V., Lozinskaya N.A., Beyshenova G.A., Nesterova T.V., Effect of melatonin instillations on the clinical course of experimental uveitis and biochemical processes in tears and aqueous humor, Biomeditsinskaya khimiya, 2016, vol: 62(2), 164-168.
References
 2017(Vol:63)
 2016(Vol:62)
 2015(Vol:61)
 2014(Vol:60)
 2013(Vol:59)
 2012(Vol:58)
 2011(Vol:57)
 2010(Vol:56)
 2009(Vol:55)
 2008(Vol:54)
 2007(Vol:53)
 2006(Vol:52)
 2005(Vol:51)
 2004(Vol:50)
 2003(Vol:49)