The profile of plasma non-esterified fatty acids in children with different terms of type 1 diabetes mellitus

   


1. Department of Biology, M.V. Lomonosov Moscow State University, Moscow, Russia; Institution of Biomedical Problems, Moscow, Russia
2. Morozov Children's Hospital, Moscow, Russia
3. Research Institute of Human Morphology of the Russian Academy of Medical Sciences, Moscow, Russia; Institution of Biomedical Problems, Moscow, Russia
Type: Clinical and diagnostic research
DOI: 10.18097/PBMC20166202206      UDK: 665.12      PubMed Id: 27143381
Year: 2016 vol: 62  issue:2  pages: 206-211
Abstract: Composition and quantitative content of non-esterified fatty acids (NEFA) were investigated in plasma samples of healthy children (12) and children with type 1 diabetes mellitus (DM1) (31) by gas chromatography (GC) after preliminary NEFA solid-phase extraction from plasma lipids. There was a significant (p<0.001) 1.6-fold increase in the total level of NEFA regardless of the disease duration. In the group of DM1 children with the disease period less than 1 year there was an increase in the arachidonic acid (20:4) content (30%) and the oleic acid trans-isomer (18:1) content (82%), and also a decrease in the docosahexaenoic acid (22:6 n3) content (26% ) and the docosapentaenoic acids (22:5 n-6) content (60%). In the group of DM1 children with prolonged course of this disease the altered NEFA levels returned to the normal level
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Reference: Akmurzina V.A., Petryairina E.E., Saveliev S.V., Selishcheva A.A., The profile of plasma non-esterified fatty acids in children with different terms of type 1 diabetes mellitus, Biomeditsinskaya khimiya, 2016, vol: 62(2), 206-211.
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