Fibrinogen/fibrin-specific enzymes from copperhead (Agkistrodon halys halys) and cobra (Naja oxiana eichwald) snake venoms

   


1. Sadykov Institute of Bioorganic Chemistry, Uzbekistan Academy of Sciences, Tashkent, Republic of Uzbekistan
Type: Experimental study
DOI: 10.18097/PBMC20166203259      UDK: 577.1:615.919      PubMed Id: 27420616
Year: 2016 vol: 62  issue:3  pages: 259-264
Abstract: Ability of fractions of cobra’s (Naja oxiana Eichwald) and copperhead snake’s (Agkistrodon halys halys) venoms to hydrolyze fibrinogen/fibrin was studied. In cobra’s snake a component with molecular mass of nearly 60 kDa was found to hydrolyze a-chain of fibrinogen but failed to hydrolyze casein/azocasein and fibrin. A fibrinogen-specific metalloproteinase, the enzyme was inhibited by EDTA. Cobra’s venom reduced the mass of donor’s fresh blood clots. The copperhead snake’s venom and the fractions obtained by gel-filtration (HW-50) and ion exchange chromatography (DEAE-650) were found to hydrolyze casein/azocasein, a- and b-chains of fibrinogen/fibrin and donor’s blood clots. The results from the study of the venom and proteolytically active fractions are the evidence for a thrombolytic potential in a copperhead snake’s venom.
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Reference: Yunusova E.S., Sadykov E.S., Sultanalieva N.M., Shkinev A.V., Fibrinogen/fibrin-specific enzymes from copperhead (Agkistrodon halys halys) and cobra (Naja oxiana eichwald) snake venoms, Biomeditsinskaya khimiya, 2016, vol: 62(3), 259-264.
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