Implication of integrin alpha5beta1 signal pathways in proliferation and apoptosis of MCF-7/Dox human breast carcinoma cells

   


1. Institute of Biomedical Chemistry, Moscow, Russia
Type: Experimental study
DOI: 10.18097/PBMC20166203272      UDK: 577.24      PubMed Id: 27420618
Year: 2016 vol: 62  issue:3  pages: 272-278
Abstract: In MCF-7/Dox human breast carcinoma cells, down-regulation of integrin alpha5beta1 and inhibition of epidermal growth factor receptor (EGFR) markedly reduced rates of cell proliferation. Mitotic cycle analysis showed that alpha5beta1 down-regulation resulted in cell cycle arrest at the S phase, followed by a significant increase in the population of apoptotic cells (subG1 population). Inhibition of EGFR activity also caused cell cycle arrest at the S-phase but without any increase in the subG1 population. Down-regulation of alpha5beta1 and EGFR inhibition resulted in a significant decrease of cell content of the active (phosphorylated) forms of FAK and Erk protein kinases. The data obtained suggest that alpha5beta1 integrin is implicated in cell growth control via inhibition of apoptotic cell death and through EGFR activation.
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Reference: Kozlova N.I., Morozevich G.E., Ushakova N.A., Gevorkian N.M., Berman A.E., Implication of integrin alpha5beta1 signal pathways in proliferation and apoptosis of MCF-7/Dox human breast carcinoma cells, Biomeditsinskaya khimiya, 2016, vol: 62(3), 272-278.
This paper is also available as the English translation:10.1134/S1990750816030082
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