Regulation of ABCA1 and ABCG1 gene expression in the intraabdominal adipose tissue

   


1. Konstantinov Petersburg Nuclear Physics Institute, National Research Center “Kurchatov Institute”, Orlova Roshcha, Gatchina, Russia; Pavlov First Saint Petersburg State Medical University, Saint Petersburg, Russia
2. Pavlov First Saint Petersburg State Medical University, Saint Petersburg, Russia
3. Konstantinov Petersburg Nuclear Physics Institute, National Research Center “Kurchatov Institute”, Orlova Roshcha, Gatchina, Russia
Type: Experimental study
DOI: 10.18097/PBMC20166203283      UDK: 577.218      PubMed Id: 27420620
Year: 2016 vol: 62  issue:3  pages: 283-289
Abstract: Tissue specific expression of genes encoding cholesterol transporters ABCA1 and ABCG1 as well as genes encoding the most important transcriptional regulators of adipogenesis – LXRa, LXRb, PPARg and RORa has been investigated in intraabdominal adipose tissue (IAT) samples.A direct correlation between the content of ABCA1 and ABCG1 proteins with RORa protein level (r=0.480, p<0.05; r=0.435, p<0.05, respectively) suggests the role of the transcription factor RORa in the regulation of IAT ABCA1 and ABCG1 protein levels. ABCA1 and ABCG1 gene expression positively correlated with obesity indicators such as body mass index (BMI) (r=0.522, p=0.004; r=0.594, p=0.001, respectively) and waist circumference (r=0.403, p=0.033; r=0.474, p=0.013, respectively). The development of obesity is associated with decreased IAT levels of RORa and LXRb mRNA (p=0.016 and p=0.002, respectively). These data suggest that the nuclear factor RORa can play a significant role in the regulation of cholesterol metabolism and control IAT expression of ABCA1 and ABCG1, while the level of IAT LXRb gene expression may be an important factor associated with the development of obesity.
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Reference: Miroshnikova V.V., Panteleeva A.A., Bazhenova E.A., Demina E.P., Usenko T.S., Nikolaev M.A., Semenova I.A., Neimark A.E., He J., Belyaeva O.D., Berkovich O.A., Baranova E.I., Pchelina S.N., Regulation of ABCA1 and ABCG1 gene expression in the intraabdominal adipose tissue, Biomeditsinskaya khimiya, 2016, vol: 62(3), 283-289.
This paper is also available as the English translation:10.1134/S199075081604003X
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