Oncolytic viruses for therapy of malignant glioma

   


1. Pirogov Russian National Research Medical University, Moscow, Russia
2. Serbsky Federal Medical Research Center for Narcology and Psychiatry, Moscow, Russia
3. Engelhardt institute of molecular biology RAS, Moscow, Russia
4. Pirogov Russian National Research Medical University, Moscow, Russia; Serbsky Federal Medical Research Center for Narcology and Psychiatry, Moscow, Russia
Type: Review
DOI: 10.18097/PBMC20166204376      UDK: 61:578.7; 616.006      PubMed Id: 27562991
Year: 2016 vol: 62  issue:4  pages: 376-390
Abstract: Effective treatment of malignant brain tumors is still an open problem. Location of tumor in vital areas of the brain significantly limits capasities of surgical treatment. The presence of tumor stem cells resistant to radiation and anticancer drugs in brain tumor complicates use of chemoradiotherapy and causes a high rate of disease recurrence. A technological improvement in bioselection and production of recombinant resulted in creation of viruses with potent oncolytic properties against glial tumors. Recent studies, including clinical trials, showed, that majority of oncolytic viruses are safe. Despite the impressive results of the viral therapy in some patients, the treatment of other patients is not effective; therefore, further improvement of the methods of oncolytic virotherapy is necessary. High genetic heterogeneity of glial tumor cells even within a single tumor determines differences in individual sensitivity of tumor cells to oncolytic viruses. This review analyses the most successful oncolytic virus strains, including those which had reached clinical trials, and discusses the prospects for new approaches to virotherapy of gliomas.
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Reference: Sosnovtceva A.O., Grinenko N.F., Lipatova A.V., Chumakov P.M., Chekhonin V.P., Oncolytic viruses for therapy of malignant glioma, Biomeditsinskaya khimiya, 2016, vol: 62(4), 376-390.
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