Abstract: Fibroblast growth factors belong to a family of growth factors that are involved in various processes in organism and have a wide range of biological functions. Specifically for pancreas, FGFs are important during both organogenesis and carcinogenesis. One of the main characteristic of pancreatic cancer, is it close interaction between cancer and stromal cells via different factors, including FGF. Pathological changes in FGF/FGFR signaling pathway is a complex process. The remodeling effects and stimulation of tumor growth are mostly depend not only on types of receptors, but also from their isoforms. FGF/FGFR signaling pathway is a perspective specific marker for cancer progression, and a potential drug target, which can be used for treatment of pancreatic cancer.
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Reference: Gnatenko D.A., Kopantsev E.P., Sverdlov E.D., Role of fibroblast growth factors in pancreatic cancer, Biomeditsinskaya khimiya, 2016, vol: 62(6), 622-629.
20. Holzmann K., Grunt T., Heinzle C., Sampl S., Steinhoff H., Reichmann N., Kleiter M., Hauck M., Marian B. (2012) J. Nucl. Acids, 2012, 950508. CrossRef Scholar google search
21. Ishiwata T., Matsuda Y., Yamamoto T., Uchida E., Korc M., Naito Z. (2012) Am. J. Pathol., 180, 1928-1941. CrossRef Scholar google search
43. Zhou L., Yao L.T., Liang Z.Y., Zhou W.X., You L., Shao Q.Q., Huang S., Guo J.C., Zhao Y.P. (2015) Internat. J. Clin. Exp. Pathol., 8(11), 14640-14648. Scholar google search
44. Kostrzewa M., Müller U. (1998) Mammalian genome: Оff. J. Internat. Mammalian Genome Soc., 9(2), 131-135. CrossRef Scholar google search
45. Bange J., Prechtl D., Cheburkin Y., Specht K., Harbeck N., Schmitt M., Knyazeva T., Müller S., Gärtner S., Sures I. et al. (2002) Cancer Res., 62(3), 840-847. Scholar google search
46. Wang J., Stockton D.W., Ittmann M. (2004) Clin. Сancer Res.: Off. J. Am. Ass. Cancer Res., 10(18 Pt 1), 6169-6178. Scholar google search
47. da Costa Andrade V.C., Parise O.Jr, Hors C.P., de Melo Martins P.C., Silva A.P., Garicochea B. (2007) Exp. Mol. Pathol., 82(1), 53-57. CrossRef Scholar google search
48. Serra S., Zheng L., Hassan M., Phan A.T., Woodhouse L.J., Yao J.C., Ezzat S., Asa S.L. (2012) Cancer Res., 72(22), 5683-5691. CrossRef Scholar google search
49. Motoda N., Matsuda Y., Onda M., Ishiwata T., Uchida E., Naito Z. (2011) Internat. J. Oncol., 38(1), 133-143. Scholar google search
50. Xu Z., Pothula S.P., Wilson J.S., Apte M.V. (2014) W. J Gastroenterol., 20(32), 11216-11229. Scholar google search
53. Compagni A., Wilgenbus P., Impagnatiello M.A., Cotten M., Christofori G. (2000) Cancer Res., 60(24), 7163-7169. Scholar google search
54. Mateescu G., Comănescu M., Mehedinþi R., Niculescu Z., Bold A., Panduru L., Cernea D. (2010) Rom. J. Morphol. Embryol., 51(2), 303-307. Scholar google search
55. Abuharbeid S., Czubayko F., Aigner A. (2006) Int. J. Biochem. Cell Biol., 38(9), 1463-1468. CrossRef Scholar google search
57. Tassi E., Henke R.T., Bowden E.T., Swift M.R., Kodack D.P., Kuo A.H., Maitra A., Wellstein A. (2006) Cancer Res., 66(2), 1191-1198. CrossRef Scholar google search
58. Bono F., De Smet F., Herbert C., De Bock K., Georgiadou M., Fons P., Tjwa M., Alcouffe C., Ny A., Bianciotto M. et al. (2013) Cancer Cell, 23(4), 477-488. CrossRef Scholar google search
59. Pan FGFR Kinase Inhibitor BGJ398 and Combination Chemotherapy in Treating Patients With Untreated Metastatic Pancreatic Cancer https://clinicaltrials.gov/ct2/show/NCT02575508. Scholar google search