Impairments of placental amino acid metabolism in fetal growth restriction


1. Rostov Scientific-Research Institute of Obstetrics and Pediatrics
Type: Clinical and diagnostic research
DOI: 10.18097/PBMC20176303266      PubMed Id: 28781260
Year: 2017 vol: 63  issue:3  pages: 266-271
Abstract: The content of the amino acids in the placenta during physiological pregnancy and fetal growth restriction (FGR) has been investigated my means of the method of ion-exchange chromatography. It has been found that in FGR the placental amino acid pool is characterized by a decreased content of arginine, proline, alanine, serine, cysteine, methionine, tryptophan, leucine, threonine, tyrosine, phenylalanine, glutamine and an increased content of dicarboxylic amino acids, lysine, histidine and glycine. These changes are accompanied by altered activity of some enzymes of amino acid metabolism, and the degree of these changes correlates with the level of corresponding amino acids.
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Reference: Pogorelova T.N., Gunko V.O., Avrutskaya V.V., Kaushanskaya L.V., Durnitsyna O.A., Impairments of placental amino acid metabolism in fetal growth restriction, Biomeditsinskaya khimiya, 2017, vol: 63(3), 266-271.
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