Comparative sub-population analysis of exosomes from blood plasma of cancer patients

   


1. Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of Russian Academy of Sciences, Novosibirsk, Russia; Novosibirsk State University, Novosibirsk, Russia
2. Tomsk Cancer Research Institute, Tomsk, Russia
3. Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of Russian Academy of Sciences, Novosibirsk, Russia
Type: Review
DOI: 10.18097/PBMC20186401110      PubMed Id: 29460840
Year: 2018 vol: 64  issue:1  pages: 110-114
Abstract: To increase the sensitivity and specificity of the developed methods for diagnosis of oncological diseases using exosomes of blood, a stage of pre-selection of tumor exosomes from a common pool of circulating microvesicles is required. In the present work, universal proteins have been identified, their expression has been increased in the exosomes of patients with colorectal cancer, head and neck squamous cell carcinomas, and lung cancer. The use of antibodies against major exosomal proteins will further develop a simple and high-performance method of affinity isolation of tumor exosomes.
Download PDF:
Reference: Tamkovich S.N., Yunusova N.V., Somov A.K., Kakurina G.V., Kolegova E.S., Tugurova E.A., Laktionov P.P., Kondakova I.V., Comparative sub-population analysis of exosomes from blood plasma of cancer patients, Biomeditsinskaya khimiya, 2018, vol: 64(1), 110-114.
This paper is also available as the English translation:10.1134/S1990750818020130
References
 2018(Vol:64)
 2017(Vol:63)
 2016(Vol:62)
 2015(Vol:61)
 2014(Vol:60)
 2013(Vol:59)
 2012(Vol:58)
 In press