The role of exosomal tetraspanins and proteases in tumor progression

   


1. Cancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia; Siberian State Medical University, Tomsk, Russia
2. Cancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia
3. Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of Russian Academy of Sciences, Novosibirsk, Russia; Novosibirsk State University, Novosibirsk, Russia; Novosibirsk State Medical University, Novosibirsk, Russia
Type: Review
DOI: 10.18097/PBMC20186402123      PubMed Id: 29723143
Year: 2018 vol: 64  issue:2  pages: 123-133
Abstract: Major (CD9, CD63, CD81) and others (CD82, CD151, Tspan8) tetraspanins are widely represented in exosomes, where they interact with various proteins and form functional tetraspanin complexes. Tetraspanin complexes include proteases. Tetraspanin-associated exosomal proteases (ADAM proteases, MMPs, EMMPRIN) play an important role in the processes of cell motility, migration, invasion and formation of metastases. Also, a significant contribution to tumor progression is made by proteases that are not associated with tetraspanins. They destabilize intercellular contacts, promote migration and invasion of tumor cells, participate in the regulation of the expression IGF-I, VEGF and transcription factors activation/deactivation. The role of other proteases of exosomes in the processes of tumor progression is being clarified.
Download PDF:
Reference: Yunusova N.V., Tugutova E.A., Tamkovich S.N., Kondakova I.V., The role of exosomal tetraspanins and proteases in tumor progression, Biomeditsinskaya khimiya, 2018, vol: 64(2), 123-133.
References
 2018(Vol:64)
 2017(Vol:63)
 2016(Vol:62)
 2015(Vol:61)
 2014(Vol:60)
 2013(Vol:59)
 2012(Vol:58)
 In press