Hepatoprotective activity of aqueous extract from Caragana jubata (Pall.) Poir. shoots in the model of acute hepatitis induced by acetaminophen in rats

   


1. Sechenov First Moscow State Medical University, Moscow, Russia
2. Pirogov Russian National Research Medical University, Moscow, Russia
Type: Experimental study
DOI: 10.18097/PBMC20186403241      PubMed Id: 29964259
Year: 2018 vol: 64  issue:3  pages: 241-246
Abstract: The aim of the study was to investigate the hepatoprotective activity of an aqueous extract of Caragana jubata (Pall.) Poir. Acute experimental hepatitis was induced by acetaminophen administration of 1000 mg/kg. Studies were conducted in white Wistar rats. The aqueous extract of C. jubata demonstrated the hepatoprotective effect, comparable to that of the reference preparation “Carcil”. This was manifested by the normalization of biochemical blood parameters (ALT, AST, alkaline phosphatase, cholesterol, total bilirubin) and antioxidant activity of liver homogenates, determined by the method based on oxidation of luminol induced by 2,2¢-azo-bis-2-amidinopropane. Normalization of morphofunctional indices was also shown in a histological study of liver of rats that received aqueous extract from C. jubata.
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Reference: Kakorin P.A., Babenkova I.V., Teselkin Y.O., Ramenskaya G.V., Demura T.A., Kukes V.G., Hepatoprotective activity of aqueous extract from Caragana jubata (Pall.) Poir. shoots in the model of acute hepatitis induced by acetaminophen in rats, Biomeditsinskaya khimiya, 2018, vol: 64(3), 241-246.
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