Concentration of several osteotropic growth factors, markers of osteogenesis and biologically active molecules in the blood serum of patients with congenital pseudarthrosis of tibia during orthopaedic treatment with combined technologies

   


1. Russian Ilizarov Scientific Center for Restorative Traumatology and Orthopaedics, Kurgan, Russia
2. Russian Ilizarov Scientific Center for Restorative Traumatology and Orthopaedics, Kurgan, Russia; Tyumen State Medical University, Tyumen, Russia
Type: Clinical and diagnostic research
DOI: 10.18097/PBMC20186406525      PubMed Id: 30632981
Year: 2018 vol: 64  issue:6  pages: 525-533
Abstract: Congenital pseudarthrosis of tibia is a genetic, systemic pathology with impaired bone remodeling and unknown pathogenetic mechanisms. Orthopaedic treatment of the disease can fail in some cases. The process of bone remodeling is known to occur under control of local and systemic growth factors, and we sought to explore several osteotropic growth factors, markers of osteogenesis and biologically active molecules in the blood serum of patients with congenital pseudarthrosis of tibia. The study included 12 patients with congenital pseudarthrosis of tibia and anatomical shortening of 2.5±1.1 cm. The' age of patients ranged from 7 years to 18 years. Blood serum was used for enzyme immunoassay analysis. The own blood serum levels of 103 conditionally healthy individuals (of mean age of 13.0±0.27 years) were considered as the norm. Greater changes in the concentration were detected among vascular endothelial and transforming growth factors. The patients showed imbalance in serum TGF, low reparative potential of bone tissue due to osteoclast activation prevailing over differentiation of osteoblasts, progenitor and mesenchymal cells. Dynamics in serum concentration of IGF at the time of frame removal indicated to terminating osteoblast activation and collagen synthesis and concomitant active bone restructuring.
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Reference: Vykhovanets E.P., Luneva S.N., Nakoskina N.V., Borzunov D.Yu., Mokhovikov D.S., Concentration of several osteotropic growth factors, markers of osteogenesis and biologically active molecules in the blood serum of patients with congenital pseudarthrosis of tibia during orthopaedic treatment with combined technologies, Biomeditsinskaya khimiya, 2018, vol: 64(6), 525-533.
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