Лизосомные цистеиновые протеиназы при неопластической трансформации 1. ГУ НИИ биомедицинской химии им. В.Н. Ореховича РАМНТип: Обзор УДК: Идентификатор PubMed: 16342665 Год: 2005 том: 51 выпуск :5 страницы: 485-500Реферат: Суммированы данные, касающиеся классификации, свойств, структуры и биологических функций папаин-подобных лизосомных цистеиновых протеиназ (катепсинов) млекопитающих. Наиболее изучены катепсины В, Н, L, S и К. Обсуждаются особенности регуляции лизосомных цистеиновых протеиназ, в частности, регуляции специфическими эндогенными ингибиторами. Рассматривается участие этих ферментов в развитии физиологических и патологических процессов. Представлены данные относительно роли лизосомных цистеиновых протеиназ и их ингибиторов при неопластической трансформации. Обсуждается возможность использования эндогенных ингибиторов катепсинов как основы для создания противоопухолевых терапевтических средствЗагрузить PDF: Ссылка: Дилакян Э.А., Цветкова И.В., Лизосомные цистеиновые протеиназы при неопластической трансформации, Биомедицинская химия, 2005, том: 51(5), 485-500.
Список литературы
Открыть 1. Rawlings N.D., Barrett A.J. (1994) Methods Enzymol., 244, 461- 486. Scholar google search 2. Willstatter R., Bamann E., (1929) Hoppe-Sayler’sZ. Physiol. Chem., 180, 127-143. Scholar google search 3. Turk V., Bode W. (1993) In: Innovations in proteinases and their inhibitors. Walterde Gruyter, Berlin, рр. 161-168. Scholar google search 4. McGrath M. (1999) Annu. Rev. Biophys. Biomol. Struct., 28, 181-204. Scholar google search 5. Turk B., Turk D., Turk V. (2000) Biochim. Biophys. Acta, 1477, 98-111. Scholar google search 6. Turk V., Turk B., Turk D. (2001) EMBO J., 20, 4629-4633. Scholar google search 7. Локшина Л.А. (1991) Вопросы мед.химии, 37(6) , 15-21. Scholar google search 8. Baicci A., Horler A., Lang A. et al. (1995) Ann. Rheum. Dis., 54, 281-288. Scholar google search 9. Saftig P., Hunzicker E., Welmeyer O. et al. (1998) Proc. Natl. Acad. Sci. USA , 87, 13453-13458. Scholar google search 10. Takeda A., Jimi T., Wakayama Y. et al. (1992) Biochem. J., 288, 643-648 Scholar google search 11. Cataldo A.M., Nixon R.A. (1990) Proc. Natl. Acad. Sci. USA, 87, 3861-3865. Scholar google search 12. Turk B., Turk V., Turk D. (1997) Biol. Chem., 378, 141-150. Scholar google search 13. Berti P.J., Storer A.C. (1995) J. Mol. Biol., 246, 273-283 Scholar google search 14. Karrer K.M., Peiffer S.L., DiTomas M.E. (1993) Proc. Natl. Acad. Sci USA, 90, 3063-3067. Scholar google search 15. Wex T., Levy B., Bromme D. (1999) Biochem. Biophys. Res. Commun., 259, 401-407. Scholar google search 16. Sivaraman J., Nagler D.K., Zhang R., Menard R., Cygler M. (2000) J. Mol. Biol., 295, 939-951. Scholar google search 17. Chapman H.A., Riese J.P., . ShiG.-P(1997) Annu. Rev. Physiol., 59, 63-88 Scholar google search 18. Dolenc I., Turk B., Pungercic G., Ritonja A., Turk V. (1995) J. Biol. Chem., 270 , 21626-21631. Scholar google search 19. Wiederanders B., Bromme D., Kirschke H., Kalkkinen N. et al. (1991) FEBS Lett., 286, 189-192. Scholar google search 20. Brocklehurst K., (1994) Protein Eng., 7, 291-299. Scholar google search 21. Pintiglang S., WattsA.B., Patel M., Raid J. et al. (1997) Biochemistry, 36, 9968-9982. Scholar google search 22. Turk D., Podobnic M., Popovic T., Katanuma N., Bode W., et al. (1995) Biochemistry, 34, 4791-4797. Scholar google search 23. Yamamoto A., Hara T., Tomoo K. , Ishida T., Fujii T. et al. (1997) J. Biochem., 121, 974-977. Scholar google search 24. Otto H.-H., Schirmeister T. (1997) Chem. Rev., 97, 133-172. Scholar google search 25. Klemencic I., Carmona A.K., Cezari M.N.S. et al. (2000) Eur. J. Biochem., 267, 5404-5412 Scholar google search 26. Musil D., Zucic D., Turk. D., Ench R., Mayar L., Huber R . et al. (1991) EMBOJ., 10, 2321-2330. Scholar google search 27. Guncar G., Podobnik M., Pungercar J., Strakelj B., Turk V. et al. (1998) Structure, 6, 51-61. Scholar google search 28. Turk D., Podobnik M., Kuhelj R., DolinarM. et al. (1996) FEBS Lett., 384, 211-214. Scholar google search 29. Kominami E., TsukaharaT., Hara K., KatunamaN. (1988) FEBS Lett., 231, 225-228. Scholar google search 30. Nishimura Y., Kawabata T., Kato K. (1988) Arch. Biochem. Biophys., 261, 64-71. Scholar google search 31. GuozzoJ.W., Tao K., Wu Q., Yuong W., et al. (1995) J. Biol. Chem., 270, 15611-15619. Scholar google search 32. Tao K., Stearns N.A., Dong J., Wu Q.L., Sahagian G.G., (1994) Arch. Biochem. Biophys., 311, 19-27. Scholar google search 33. Fox T., de Miguel E., Mort J.S., Storer A.C. (1992) Biochemistry, 31, 12571-12576. Scholar google search 34. Cygler M, Mort J.S. (1997) Biochimie, 79, 645-652. Scholar google search 35. Rowan A.D., Mason P., Mach L., Mort J.S. (1992) J. Biol. Chem., 269, 15993-15999. Scholar google search 36. Podobnic M., Kuhelj R., Turk V., Turk D. (1997) J. Mol. Biol., 271, 774-788. Scholar google search 37. Cygler M., Siviraman J., Grochulski P., Coulombe R. et al. (1996) Structure, 4, 405-416. Scholar google search 38. LaLonde J.M., Zhao B., Janson C.A., D’Alessio K.J., M.S.Queney et al. (1999) Biochemistry, 38, 862-869. Scholar google search 39. Nagler D., Tam W., Storer A.P., Krupa J.C. et al. (1999) Biochemistry, 38, 4868-4874. Scholar google search 40. Dahl S.W., HalkierT., LauritzenC., Dolenc I. et al. (2001) Biochemistry, 40, 1671-1678. Scholar google search 41. Wang B., Shi G.P., Yao P.M., Li Z., Chapman H.A., et al. (1998) J. Biol. Chem., 273, 32000-32008. Scholar google search 42. Turk B., Bieth J.G., Bjork I., Dolenc I. et al. (1995) Biol. Chem. Hoppe-Seyler, 376, 225-230. Scholar google search 43. Bromme D., Okamoto K., Wang B.B., Biroc S. (1996) J. Biol. Chem., 271, 2126-2132. Scholar google search 44. Kirschke H., WiederandersB., Bromme D., Rinne A. (1989) Biochem. J., 264, 467-473. Scholar google search 45. Turk B., Dolenc I., Lenarcic B., Krizaj I. et al. (1999) Eur. J. Biochem., 259, 926-932. Scholar google search 46. Turk V., Bode W. (1991) FEBS Lett., 285, 213-219. Scholar google search 47. Lenarcic B., Bevec T. (1998) Biol. Chem., 379, 105-111. Scholar google search 48. Mason R.V. (1989) Arch. Biochem. Biophys., 273, 367-374. Scholar google search 49. Stubbs M.T., Laber B., Bode W., Huber R. et al. (1990) EMBO J., 9, 1939-1947. Scholar google search 50. GuncarG., PungercicG., KlemencicI., Turk V., Turk D. (1999) EMBOJ., 18, 793-803. Scholar google search 51. BevecT., StokaV., PungercicG., DolencI., Turk V. (1996) J. Exp. Med. , 183, 1331-1338. Scholar google search 52. Schick C., Pemberton P.A., Shi G.P., Kamachi Y. et al. (1998) Biochemistry, 37, 5258-5266. Scholar google search 53. Suminami Y., Kishi F., Sekiguchi K., Kato H. (1991) Biochem. Biophys. Res.Commun., 181, 51-58. Scholar google search 54. Delaria K., Fiorentino L., Wallace P. et al. (1994) J. Biol. Chem., 269, 25172-25177. Scholar google search 55. Schick C., Bromme D., Bartuski A.J., Uemura Y. et al. (1998) Proc. Natl. Acad. Sci. USA, 95, 13465-13470. Scholar google search 56. TakedaA., YamamotoT., NakamuraY., TakahashiT.et al. (1995) FEBS Lett., 359, 78-80. Scholar google search 57. ChapmanH.A., MungerJ.S., Shi G.P. (1994) Am. J. Resp. Crit. Care. Med. , 150, 155-159. Scholar google search 58. Tezuka K., TezukaY., MaejimaA., Sato T. et al. (1994) J. Biol. Chem., 269, 1106-1109. Scholar google search 59. Linnevers C., Smeekens S.P., Bromme D. (1997) FEBS Lett., 405, 253-259. Scholar google search 60. Santamaria I., Velasco G., Cazorla M. et al. (1998) Cancer Res., 58, 1624-1630. Scholar google search 61. Bromme D., Li Z., Barners M., Mehler E. (1999) Biochemistry, 38, 2377-2385. Scholar google search 62. Slee E.A., Harte M.T., Kluck K.M. et al. (1999) J. Cell Biol., 144, 281-292. Scholar google search 63. DeussingJ., Roth W., Saftig P. et al. (1998) Proc. Natl. Acad. Sci. USA, 95, 4516-4521. Scholar google search 64. Nakagawa T.Y., Roth W., Wong P. et al. (1998) Science, 280, 450-453. Scholar google search 65. Nakagawa T.Y., Brissette W.H., Lira P.D. et al. (1999) Immunity, 10, 207-217. Scholar google search 66. Gelb B.D., Shi G.P., ChapmanH.A. and Desnick R.J. (1996) Science, 273, 1236-1238. Scholar google search 67. Roth V. (2000) FASEB J., 14, 2074-2086. Scholar google search 68. Buck M.R., Karustis D.G., Day N.A., Honn K.V., Sloane B.F. (1992) Biochem.J., 282, 273-278. Scholar google search 69. Authier F., Mort J.S., Bell A.W. et al. (1995) J. Biol. Chem., 270, 15798-15807. Scholar google search 70. Pham C.T., Ley T.Y. (1999) Proc. Natl. Acad. Sci. USA, 96, 8627-8632. Scholar google search 71. Jutras I., Reudelhuber T.L. (1999) FEBS Lett., 443, 48-52. Scholar google search 72. Dunn A.D., Grutchfield H.E., Dunn J.T. (1991) J. Biol. Chem., 266, 20198-20204. Scholar google search 73. Teppel C., Bromme D., Herzog W. and Brix C. (2000) Cell Sci., 113, 4487-4498. Scholar google search 74. Felbor U., Dreier L., Bryant R.A. et al. (2000) EMBO J., 19, 1187-1194. Scholar google search 75. Shi JG.P., Villadangos J.A., Dranoff G. et al. (1999) Immunity, 10, 197-206. Scholar google search 76. Riese R., Wolf P., Bromme D. et al. (1996) Immunity, 5, 357-365. Scholar google search 77. Riese R.J., MitchellR.N., VilladangosJ.A. et al. (1998) J. Clin. Invest., 101, 2351-2363. Scholar google search 78. Villadangos J.A., RieseR.J., PetersC., ChapmanH.A., (1997) J. Exp. Med. , 186, 549-560. Scholar google search 79. Pierre P., Mellman I. (1998) Cell, 93, 1135-1145. Scholar google search 80. Shi G.P., Bryant R.A., Riese R., VerhelstS. et al. (2000) J. Exp. Med. , 191, 1177-1186. Scholar google search 81. Steller H. (1995) Science, 267, 1445-1449. Scholar google search 82. Ishisaka R., Kanno T., Akiyama J. et al. (2001) Biochemistry (Tokyo) , 129, 35-41. Scholar google search 83. Li W., Yuan X.M., Nordgren G., Dalen H. et al. (2000) FEBS Lett., 470, 35-39. Scholar google search 84. Ishisaka R., Utsumi T., Yabuki M., Kanno T. et al. (1998) FEBS Lett., 435, 233-236. Scholar google search 85. IshisakaR., UtsumiT., KannoT., Arita K. et al. (1999) Cell Struct. Funct., 24, 465-470. Scholar google search 86. Katunuma N., Matsui A., Utsumi K., Qang L.T. et al. (2000) Adv. Enzyme Regul., 40, 427-438 Scholar google search 87. Nixon R.A., Cataldo A.M. (1993) Ann. NY Acad. Sci., 679, 87-109. Scholar google search 88. Pennaechio L.A., Beuley D.M., Higgins K.M. (1998) Nat. Genet., 20, 251-258. Scholar google search 89. Pham C.T., Thomas D.A., MercerJ.D., Ley T.Y (1998) J. Biol. Chem., 273, 1629-1633. Scholar google search 90. Schotte P., Van Criekinge W., Van de Graen M. et al. (1998) Biochem. Biophys. Res. Commun., 251, 379-387. Scholar google search 91. Vancompernolle K., Van Herreweghe F., Pynaer G.et al. (1998) FEBS Lett., 438, 150-158. Scholar google search 92. Shibata M., Kanamori S., Isabara K., et al. (1998) Biochem. Biophys. Res.Commun., 251, 199-203. Scholar google search 93. Hanahan D., Weinberg R.A. (2000) Cell, 100, 57-70. CrossRef Scholar google search 94. Sloane B.F., Berquin I.M. (1993) In: Proteolysis and Protein Turnover, PortlandPress Proceedings, pp. 225-231. Scholar google search 95. Farinati F., Herszenyi L., Plebani M., et al. (1999) Carcinogenesis, 17, 2581-2587. Scholar google search 96. FingletonB.M., Heppner-CossK.J., CrawfordH.C. et al. (1999) APMIS, 107, 102-110. Scholar google search 97. Koblinski J.E., Ahram M., Sloane B.F. (2000) Clin. Chim. Acta, 291, 113-135. Scholar google search 98. Ishidon K., Kominami E. (1998) Biol. Chem., 379, 131-135. Scholar google search 99. Frosch B.A., Berquin I., Emmeret-Buck M.R., Moin K., Sloane B.F., (1999) APMIS, 107, 28-37. Scholar google search 100. Dong J., Prence E.M., Sahagian G.G., (1989) J. Biol. Chem., 264, 7377-7383. Scholar google search 101. Dilakyan E.A., Zhurbitskaya V.A., Vinokurova S.V. et al. (2001) Clin. Chim. Acta, 309, 37-43. Scholar google search 102. Sloane B.F., Moin K., Sameni M., et al. (1994) J. Cell Sci., 107, 373-384. Scholar google search 103. Sameni M., Elliott E., Ziegler G. et al. (1995) Pathol. & Oncol. Res., 1, 43-53. Scholar google search 104. Podgorski I., Sloane B.F. (2003) Biochem. Soc. Symp., 70, 263-276. Scholar google search 105. Sloane B.F., Moin K., Lah T. (1994) In: Aspects of the Biochemistry and Molecular Biology of Tumors, Academic Press, San Diego, 2T, pp. 411-466. Scholar google search 106. Kane S.E., Gottesmann M., (1990) Semin. Cancer Biol., 1, 127-136. Scholar google search 107. Lloyd J.B., Mason R.W. (Eds) (1996) Biology of the lysosome. Subcellular Biochemistry 27, Plenum Press New York. Scholar google search 108. Moin K., Day N.A., Sameni M. et al. (1992) Biochem.J., 285, 427-434. Scholar google search 109. Gong Q., Chan J.S., Baykowski A.S. et al. (1993) DNA Cell Biol., 12, 299-309. Scholar google search 110. RescheleitD.K., RommerskirchW.J., WiederandersB., (1996) FEBS Lett., 394, 345-348. Scholar google search 111. Mehtani S., Gong Q., Panella J. et al. (1998) J. Biol. Chem., 273, 13236-13244. Scholar google search 112. Donchin A., Suzuki Y.I., Seki H. et al. (2000) Cancer, 36, 482-487. Scholar google search 113. Kirschke H., Eerola R., Hopsu-Havu V.K. et al. (2000) Eur. J. Cancer, 36, 787-789. Scholar google search 114. Montcorrier P., Silver I., Farnoud R. et al. (1997) Clin. Exp. Metastasis, 15, 382-392. Scholar google search 115. Menard R., Carmona E., Takebe S. et al. (1998) J. Biol. Chem., 273, 4478-4484. Scholar google search 116. Dalet-Fumeron V., Guinec N., Pagano M. (1993) FEBS Lett., 332, 251-254. Scholar google search 117. Mason R.W., MasseyS.D. (1992) Biochem. Biophys. Res. Commun., 189, 1659-1666. Scholar google search 118. Guinec N., Dalet-Fumeron V., Pagano M. (1993) Biol. Chem. Hoppe-Seyler, 374, 1135-1146. Scholar google search 119. Kobayashi H., Schmitt M., Goretzki L. et al. (1991) J. Biol. Chem., 266, 5147-5152. Scholar google search 120. Goretzki L., Schmitt M., Mann K. et al. (1992) FEBS Lett., 297, 112-118. Scholar google search 121. Eeckhout Y., Vaes G. (1977) Biochem. J., 166, 21-31. Scholar google search 122. Murphy G., Stanton H., Cowell S. et al. (1999) APMIS, 107, 38-44. Scholar google search 123. Kostoulas R., Lang A., Nagase H., Baici A. (1999) FEBS Lett., 455, 280-290. Scholar google search 124. Poltorac Z., Cohen T., Sivan R. et al. (1997) J. Biol. Chem., 272, 7151-7158. Scholar google search 125. DhanabalM., RamchandramR., WatermanM.J. (1999) J. Biol. Chem., 274, 11721-11726. Scholar google search 126. Garnero P., Borei O., Byrjalsen I. et al. (1998) J. Biol. Chem., 273, 32347-32352. Scholar google search 127. McQueney M.S., Amegadzie B.Y., D'Alessio K. et al. (1997) J. Biol. Chem., 272, 13955-13960. Scholar google search 128. Buhlding F., Walburg N., Gerber A. et al. (2000) Adv. Exp. Med. Biol., 447, 281-286. Scholar google search 129. Littlwood-EvansA.J., Bilbe J., Bowler W.B. et al. (1997) Cancer Res., 57, 5386-5390. Scholar google search 130. Krepela E. (2001) Neoplasma, 48, 332-349. Scholar google search 131. Gilmore A.P., Streuli C.H. (1998) Adhesion and apoptosis, Kluwer Academic Publishers Dordrecht, pp. 144-165. Scholar google search 132. Levicar N., Lah.T.T., Kos J. (2003) Cancer Gene Ther., 10, 141-157. Scholar google search 133. Kos J., Lah T.T. (1998) Oncol. Rep., 5, 1349-1361. Scholar google search 134. Heideman H.H., Salge U., Abrahamson M. et al. (1997) Clin. Exp. Metastasis, 15, 368-381. Scholar google search 135. Boike G., Lah T., Sloane B.F. et al. (1992) Melanoma Res., 1, 330-340. Scholar google search 136. Cox L., Sexton P.S., Green T.J., Darmini N.A. (1999) Melanoma Res., 9, 369-374. Scholar google search 137. Collela R., Cassey S.F. (2003) Biotech. Histochem., 78(2) , 101-108. Scholar google search 138. Bervar A., Zajc I., Sever N., Katanuma N. (2003) Biol. Chem., 384(3) , 447-455. Scholar google search 139. Rousselet N., Mills L., Jean D. et al. (2004) Cancer Res., 64(1) , 146-157. Scholar google search 140. Leung-Toung R., Wadzinska J., Li W. et al. (2003) Bioorg. Med. Chem., 11(24) , 5529-5537. Scholar google search 141. Thumond R.L., Sun S., Sehon C.A. et al. (2004) J. Pharmacol. Exp. Ther., 308(1) , 268-276. Scholar google search 142. Strojnik T., Zidanic B., Kos J., Lah T.T. (2001) Neurosurgery, 48, 598-605. Scholar google search 143. Foekens J.A., Kos J., Peters H.A. et al. (2002) Clin. Oncol., 16, 1013-1021. Scholar google search 144. Levicar N., Kos J., Blejec A. et al. (2002) Cancer Detect.Prev., 26, 42-49. Scholar google search 145. Kos.J., Sekirnik A., Kopotar G. et al. (2001) Br. J. Cancer, 85(8) , 1193-1200. Scholar google search 146. Flannery T., Gibson D., Mirakhur M. et al. (2003) Am. J.Pathol., 163(1) , 175-182. Scholar google search 147. Jedeszko Ch. , Sloane B.F., (2004) Biol. Chem., 385, 1017-1027. Scholar google search
