Известно о существовании, по крайней мере, двух типов гибели клеток: физиологической (апоптоз) и патологической (некроз). Нарушения апоптоза имеют прямое или косвенное отношение к патогенезу широкого круга заболеваний, что дает ключ к разработке новых терапевтических подходов. В обзоре проанализированы текущее состояние и перспективы терапевтического использования моноклональных антител, биологически активных белков, пептидных фрагментов и соединений небелковой природы, а также препаратов генонаправленного действия, которые способны модулировать апоптоз. Кроме того, обсуждается целесообразность применения апоптомодуляторов с целью повышения эффективности традиционных методов лечения.
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