Биологическая активность фитостеринов и их производных

Мехтиев А.Р.; Мишарин А.Ю.

Биологическая активность фитостеринов и их производных

Мехтиев А.Р.¹, Мишарин А.Ю.¹

1. Научно-исследовательский институт биомедицинской химии им. В.Н. Ореховича РАМН

Раздел: Экспериментальные/клинические исследование

Идентификатор PubMed: 18078065

Год: 2007 том: 53 выпуск: 5 страницы: 497-521

Обзор посвящен современному состоянию исследований биологической активности С29- и С28-стеринов растительного происхождения (фитостеринов) в организме и в клетках млекопитающих. На основании экспериментальных статей, опубликованных в последнее десятилетие, в обзоре рассматриваются следующие вопросы: фитостерины и питание; фитостерины и уровень холестерина в организме; фитостерины и абсорбция липидов в кишечнике; роль фитостеринов в регуляции метаболизма липидов; фитостерины и клетки млекопитающих в культуре; продукты окисления фитостеринов; фитоэкдистероиды и индуцированная экспрессия генов.

Загрузить PDF:

Ключевые слова: стерины, фитостерины, холестерин, метаболизм липидов

Цитирование:

Мехтиев, А. Р., Мишарин, А. Ю. (2007). Биологическая активность фитостеринов и их производных. Биомедицинская химия, 53(5), 497-521.

Переводная версия в журнале
«Biomedical Chemistry (Moscow) Supplement Series B»: 10.1007/s11828-008-1001-4

Список литературы

Ling W.H., Jones P.J. (1995) Life Sci., 57(3), 195-206. Scholar google search
Schwandt P., Richter W.O. (1995) Wien Klin. Wochenschr., 107(18), 544-548. Scholar google search
Pedersen T.R. (1995) N. Engl. J. Med., 333(20), 1350-1351. Scholar google search
Moghadasian M.H. (2000) Life Sci., 67(6), 605-615. Scholar google search
Wong N.C. (2001) Can. J. Cardiol., 17(6), 715-721. Scholar google search
Tapiero H., Townsend D.M., Tew K.D. (2003) Biomed. Pharmacother., 57(8), 321-325. Scholar google search
Ostlund R.E. (2004) Curr. Opin. Lipidol., 15(1), 37-41. Scholar google search
QuIlez J., Garcia-Lorda P., Salas-Salvado J. (2003) Clin. Nutr., 22(4), 343-351. Scholar google search
Awad A.B., Fink C.S. (2000) J. Nutr., 130(9), 2127-2130. Scholar google search
Ohshima A., Une M., Hoshita T. (1994) Hiroshima J. Med. Sci., 43(3), 81-86. Scholar google search
Sehayek E. (2003) J. Lipid Res., 44, 2030-2038. Scholar google search
Boberg K.M., Skrede B., Skrede S. (1986) Scand. J. Clin. Lab. Invest. Suppl., 184, 47-54. Scholar google search
Compassi S., Werder M., Weber F.E., Boffelli D., Hauser H., Schulthess G. (1997) Biochemistry, 36(22), 6643-6652. Scholar google search
Igel M., Giesa U., Lutjohann D., von Bergmann K. (2003) J. Lipid Res., 44(3), 533-538. Scholar google search
Sudhop T., Sahin Y., Lindenthal B., Hahn C., Luers C., Berthold H.K., von Bergmann K. (2002) Gut., 51(6), 860-863. Scholar google search
Heinemann T., Kullak-Ublick G.A., Pietruck B., von Bergmann K. (1991) Eur. J. Clin. Pharmacol., 40(1), 59-63. Scholar google search
Hakala K., Vuoristo M., Miettinen T.A. (1996) Digestion, 57(2), 83-89. Scholar google search
Hakala K., Luukkonen P., Vuoristo M., Jarvinen H., Miettinen T.A. (1997) J. Hepatol., 26(6), 1306-1312. Scholar google search
Del Puppo M., Petroni M.L., Crosignani A., Podda M. (1998) J. Lipid Res., 39(12), 2477-2482. Scholar google search
Meijer G.W., Bressers M.A., de Groot W.A., Rudrum M. (2003) Lipids, 38(7), 713-721. Scholar google search
Nissinen M., Gylling H., Vuoristo M., Miettinen T.A. (2002) Am. J. Physiol. Gastrointest. Liver Physiol., 282(6), 1009-1015. Scholar google search
Relas H., Gylling H., Miettinen T.A. (2000) Metabolism, 49(4), 473-478. Scholar google search
Moreau R.A., Hicks K.B. (2004) Lipids, 39(8), 769-776. Scholar google search
Sarkkinen E.S., Uusitupa M.I., Gylling H., Miettinen T.A. (1998) Metabolism, 47(6), 744-750. Scholar google search
Relas H., Gylling H., Miettinen T.A. (2001) Br. J. Nutr., 85(2), 141-147. Scholar google search
Mortimer B.C., Mortimer B.C., Tso P., Phan C.T., Beveridge D.J., Wen J., Redgrave T.G. (1995) J. Lipid Res., 36(9), 2038-2053. Scholar google search
Robins S.J., Fasulo J.M., Pritzker C.R., Patton G.M. (1996) J. Lipid Res., 37(1), 15-21. Scholar google search
Miettinen T.A., Tilvis R.S., Kesaniemi Y.A. (1990) Am. J. Epidemiol., 131(1), 20-31. Scholar google search
Miettinen T.A., Vanhanen H. (1994) Atherosclerosis, 105(2), 217-226 . Scholar google search
Vanhanen H.T., Blomqvist S., Ehnholm C., Hyvonen M., Jauhiainen M., Torstila I., Miettinen T.A. (1993) J. Lipid Res., 34(9), 1535-1544. Scholar google search
Gylling H., Miettinen T.A. (1994) Diabetologia, 37(8), 773-780. Scholar google search
Gylling H., Siimes M.A., Miettinen T.A. (1995) J. Lipid Res, 36(8), 1807-1812. Scholar google search
Gylling H., Miettinen T.A. (1996) J. Lipid Res., 37(8), 1776-1785. Scholar google search
Jones P.J., McDougall D.E., Ntanios F., Vanstone C.A. (1997) Can. J. Physiol. Pharmacol., 75(3), 217-227. Scholar google search
Jones P.J., Howell T., McDougall D.E., Feng J.Y., Parsons W. (1998) Metabolism, 47(6), 751-756. Scholar google search
Weststrate J.A., Meijer G.W. (1998) Eur. J. Clin. Nutr., 52(5), 334-343. Scholar google search
Nguyen T.T., Dale L.C., von Bergmann K., Croghan I.T. (1999) Mayo Clin. Proc., 74(12), 1198-1206. Scholar google search
Jankowski P., Bilo G., Bryniarski L., Bryniarska-Mirek E., Pajak A. (2000) Przegl. Lek., 57(11), 655-658 (Medline). Scholar google search
Ntanios F.Y., Duchateau G.S. (2002) Int. J. Vitam. Nutr. Res., 72(1), 32-39. Scholar google search
Mensink R.P., Ebbing S., Lindhout M., Plat J., van Heugten M.M. (2002) Atherosclerosis, 160(1), 205-213. Scholar google search
Meguro S., Higashi K., Hase T., Honda Y., Otsuka A., Tokimitsu I., Itakura H. (2001) Eur. J. Clin. Nutr., 55(7), 513-517. Scholar google search
Vaskonen T., Mervaala E., Seppanen-Laakso T., Karppanen H. (2001) Nutr. Metab. Cardiovasc. Dis., 11(3), 158-167. Scholar google search
Vaskonen T., Mervaala E., Sumuvuori V., Seppanen-Laakso T., Karppanen H. (2002) Br. J. Nutr., 87(3), 239-245. Scholar google search
Geelen A., Zock P.L., de Vries J.H., Katan M.B. (2002) Eur. J. Clin. Invest., 32(10), 738-742. Scholar google search
Sugano M., Morioka H., Ikeda I. (1977) J. Nutr., 107(11), 2011-2019. Scholar google search
Ikeda I., Nakashima-Yoshida K., Sugano M. (1985) J. Nutr. Sci. Vitaminol., 31(3), 375-384. Scholar google search
Ling W.H., Jones P.J. (1995) Atherosclerosis, 118(2), 319-331. Scholar google search
Katamoto H., Yoneda N., Shimada Y. (1991) J. Vet. Med. Sci., 53(5), 905-910. Scholar google search
Wasan K.M., Holtorf L., Subramanian R., Cassidy S.M., Pritchard P.H., Stewart D.J., Novak E., Moghadasian M.H. (2001) J. Pharm. Sci., 90(1), 23-28. Scholar google search
Ntanios F.Y., Jones P.J. (1998) Biochim. Biophys. Acta, 1390(3), 237-244. Scholar google search
Ramjiganesh T., Roy S., McIntyre J.C., Luz Fernandez M. (2001) Br. J. Nutr., 85(2), 165-172. Scholar google search
Himber J., Missano B., Rudling M., Hennes U., Kempen H.J. (1995) J. Lipid Res., 36(7), 1567-1585. Scholar google search
Volger O.L., van der Boom H., de Wit E.C., van Duyvenvoorde W., Hornstra G., Plat J., Havekes L.M., Mensink R.P., Princen H.M. (2001) Arterioscler. Thromb. Vasc. Biol., 21(6), 1046-1052. Scholar google search
Ntanios F.Y., Jones P.J., Frohlich J.J. (1998) Atherosclerosis, 138(1), 101-110. Scholar google search
Xu G., Salen G., Shefer S., Tint G.S., Nguyen L.B., Batta A.K., Pcolinsky M. (2001) Metabolism, 50(9), 1106-1112. Scholar google search
Grundy S.M., Mok H.Y. (1977) J. Lab. Clin. Med., 89(2), 354-366. Scholar google search
Hidaka H., Kojima H., Kawabata T., Nakamura T., Konaka K., Kashiwagi A., Kikkawa R., Shigeta Y. (1995) J. Atheroscler. Thromb., 2(1), 60-65. Scholar google search
Gylling H., Radhakrishnan R., Miettinen T.A. (1997) Circulation, 96(12), 4226-4231. Scholar google search
Gylling H., Miettinen T.A. (1995) Atherosclerosis, 117(2), 305-308. Scholar google search
Denke M.A. (1995) Am. J. Clin. Nutr., 61(2), 392-396. Scholar google search
Jakulj L., Trip M.D., Sudhop T., von Bergmann K., Kastelein J.J., Vissers M.N. (2005) J. Lipid Res., 46(12), 2692-2698. CrossRef Scholar google search
Patel S.B., Salen G., Hidaka H., Kwiterovich P.O., Stalenhoef A.F., Miettinen T.A., Grundy S.M., Lee M.H., Rubenstein J.S., Polymeropoulos M.H, Brownstein M.J. (1998) J. Clin. Invest., 102(5), 1041-1044. Scholar google search
Burris T.P., Eacho P.I., Cao G. (2002) Mol. Genet. Metab., 77(1-2), 13-20. Scholar google search
Berge K.E. (2003). Ann Med., 35(7), 502-511. Scholar google search
Cobb M.M., Salen G., Tint G.S., Greenspan J., Nguyen L.B. (1996) Metabolism, 45(6), 673-679. Scholar google search
Parsons H.G., Jamal R., Baylis B., Dias V.C., Roncari D. (1995) Clin. Invest. Med., 18(5), 389-400. Scholar google search
Lee M.H., Gordon D., Ott J., Lu K., Ose L., Miettinen T., Gylling H., Stalenhoef A.F., Pandya A., Hidaka H., Brewer B. Kojima H., Sakuma N., Pegoraro R., Salen G., Patel S.B. (2001) Eur. J. Hum. Genet., 9(5), 375-384. Scholar google search
Lee M.H., Lu K., Patel S.B. (2001) Curr. Opin. Lipidol., 12(2), 141-149. Scholar google search
Lee M.H., Lu K., Hazard S., Yu H., Shulenin S., Hidaka H., Kojima H., Allikmets R., Sakuma N., Pegoraro R., Srivastava A.K., Salen G., Dean M., Patel S.B. (2001) Nature Genet., 27(1), 79-83. Scholar google search
Lu K., Lee M.H., Hazard S., Brooks-Wilson A., Hidaka H., Kojima H., Ose L., Stalenhoef A.F., Mietinnen T., Bjorkhem I., Bruckert E., Pandya A., Brewer H.B., Salen G., Dean M., Srivastava A., Patel S.B. (2001) Am. J. Hum. Genet., 69(2), 278-290. Scholar google search
Berge K.E., Tian H., Graf G.A., Yu L., Grishin N.V., Schultz J., Kwiterovich P., Shan B., Barnes R., Hobbs H.H. (2000) Science, 290(5497), 1771-1775. CrossRef Scholar google search
Schmitz G., Langmann T., Heimerl S. (2001) J. Lipid Res., 42(8), 1513-1520. Scholar google search
Duan L.P., Wang H.H., Wang D.Q. (2004) J. Lipid Res., 45(7), 1312-1323. Scholar google search
Graf G.A., Yu L., Li W.P., Gerard R., Tuma P.L., Cohen J.C., Hobbs H.H. (2003) J. Biol. Chem., 278(48), 48275-48282. Scholar google search
Plosch T., Bloks V.W., Terasawa Y., Berdy S., Siegler K., van Der Sluijs F., Kema I.P., Groen A.K., Shan B., Kuipers F., Schwarz M. (2004) Gastroenterology, 126(1), 290-300. CrossRef Scholar google search
Klett E.L., Lu K., Kosters A., Vink E., Lee M.H., Altenburg M., Shefer S., Batta A.K., Yu H., Chen J., Klein R., Looije N., Oude-Elferink R., Groen A.K., Maeda N., Salen G., Patel S.B. (2004) BMC Med. (online), 2(5). Scholar google search
Ikeda I., Nakagiri H., Sugano M., Ohara S., Hamada T., Nonaka M., Imaizumi K. (2001) Metabolism 50(11), 1361-1368. Scholar google search
Yang C., Yu L., Li W., Xu F., Cohen J.C., Hobbs H.H. (2004) J. Clin. Invest., 114(6), 813-822. Scholar google search
Yu L., Hammer R.E., Li-Hawkins J., von Bergmann K., Lutjohann D., Cohen J.C., Hobbs H.H. (2002) Proc. Natl. Acad. Sci. USA, 99(25), 16237-16242. Scholar google search
Nguyen L.B., Salen G., Shefer S., Tint G.S., Ruiz F. (2001) Metabolism, 50(10), 1224-1229. Scholar google search
Nguyen L.B., Salen G., Shefer S., Bullock J., Chen T., Tint G.S., Chowdhary I.R., Lerner S. (1994) Metabolism, 43(7), 855-859. Scholar google search
Nguyen L.B., Shefer S., Salen G., Tint S.G., Batta A.K. (1998) Proc. Assoc. Am. Physicians, 110(1), 32-39. Scholar google search
Lu T.T., Repa J.J., Mangelsdorf D.J. (2001) J. Bol. Chem., 276(41), 37735-37738. Scholar google search
Repa J.J. Mangelsdorf D.J. (1999) Curr. Opin. Biotechnol., 10 (6), 557-563. Scholar google search
Peet D.J., Janowski B.A., Mangelsdorf D.J. (1998) Curr. Opin. Gen. Develop., 8, 571-575. Scholar google search
Joseph S.B., Bradley M.N., Castrillo A., Bruhn K.W., Mak P.A., Pei L., Hogenesch J., O`Connell R.M., Cheng G., Saez E., Miller J.F., Tontonoz P. (2004) Cell, 119(2), 299-309. Scholar google search
Field F.J., Born E., Mathur S.N. (1997) J. Lipid Res., 38(2), 348-360. Scholar google search
Ho S.S., Pal S. (2004) Asia Pac. J. Clin. Nutr., 13, 68. Scholar google search
Ho S.S., Pal S. (2005) Atherosclerosis, 182(1), 29-36. Scholar google search
Plat J., Nichols J.A., Mensink R.P. (2005) J. Lipid Res., 46(11), 2468-2476. Scholar google search
Plat J., Mensink R.P. (2002) FASEB J., 16(10), 1248-1253. Scholar google search
Vallett S.M., Sanchez H.B., Rosenfeld J.M., Osborne T.F. (1996) J. Biol. Chem., 271(21), 12247-12253. Scholar google search
Bennett M.K., Osborne T.F. (2000) Proc. Natl. Acad. Sci. USA, 97(12), 6340-6344. Scholar google search
Brown M.S., Goldstein J.L. (1997) Cell, 89(3), 331-340. Scholar google search
Yang C., Yu L., Li W., Xu F., Cohen J.C., Hobbs H.H. (2004) J. Clin. Invest., 114(6), 813-822. Scholar google search
Field F.J., Born E., Mathur S.N. (1997) J. Lipid Res., 38(2), 348-360. Scholar google search
Shefer S., Salen G., Bullock J., Nguyen L.B., Ness G.C., Vhao Z., Belamarich P.F., Chowdhary I., Lerner S., Batta A.K. (1994) Hepatology, 20(1), 213-219. Scholar google search
Honda A., Salen G., Nguyen L.B., Xu G., Tint G.S., Batta A.K., Shefer S. (1998) Hepatology, 27(1), 154-159. Scholar google search
Honda A., Salen G., Honda M., Batta A.K., Tint G.S., Xu G., Chen T.S., Tanaka N., Shefer S. (2000) J. Lab. Clin. Med., 135(2) 174-179. Scholar google search
Sato Y., Nishikawa K., Aikawa K., Mimura K., Murakami-Murofushi K., Arai H., Inoue K. (1995) Biochim. Biophys. Acta, 1257(1), 38-46. Scholar google search
Buhman K.F., Accad M., Farese R.V. (2000) Biochim. Biophys. Acta, 1529(2), 142-154. Scholar google search
Sakashita N., Miyazaki A., Takeya M., Horiuchi S., Chang C.C.Y., Chang T.-Y., Takahashi K. (2000) Am. J. Pathol., 156 (1), 227-236. Scholar google search
Smith J.L., Rangaraj K., Simpson R., McLean, D.J., Nathanson L.K., Stuart K.A., Scott S.P., Ramm G.A., de Jersey J. (2004) J. Lipid Res., 45(4), 686-696. Scholar google search
Temel R.E., Gebre A.K., Parks J.S., Rudel L.L. (2003) J. Biol. Chem., 278(48), 47594-47601. Scholar google search
Fernandez C., Suarez Y., Ferruelo A.J., Gomez-Coronado D., Lasuncion M.A. (2002) Biochem. J., 366(Pt 1), 109-119. Scholar google search
Shefer S., Salen G., Honda A., Batta A.K., Nguyen L.B., Tint G.S., Ioannou Y.A., Desnick R. (1998) J. Lipid Res., 39(12), 2471-2476. Scholar google search
Plosch T., Kruit J.K., Bloks V.W., Huijkman N.C., Havinga R., Duchateau G.S., Lin Y., Kuipers F. (2006) J. Nutr., 136(8), 2135-2140. CrossRef Scholar google search
Laraki L., Pelletier X., Mourot J., Debry G. (1993) Ann. Nutr. Metab., 37(3), 129-133. Scholar google search
Tamura M., Suzuki H., Itoh K. (1998) Int. J. Vitam. Nutr. Res., 68(2), 146-148. Scholar google search
Xu F., Rychnovsky S.D., Belani J.D., Hobbs H.H,, Cohen J.C., Rawson R.B. (2005) Proc. Natl. Acad. Sci. USA, 102(41), 14551-14556. Scholar google search
Awad A.B., Smith A.J., Fink C.S. (2001) Prostaglandins Leukot. Essent. Fatty Acids, 64(6), 323-330. Scholar google search
Awad A.B., Chen Y.C., Fink C.S., Hennessey T. (1996) Anticancer Res., 16(5A), 2797-2804. Scholar google search
Awad A.B., von Holtz R.L., Cone J.P., Fink C.S., Chen Y.C. (1998) Anticancer Res., 18(1A), 471-473. Scholar google search
Awad A.B., Downie A.C., Fink C.S. (2000) Int. J. Mol. Med., 5(5), 541-545. Scholar google search
Awad A.B., Roy R., Fink C.S. (2003) Oncol. Rep., 10(2), 497-500. Scholar google search
Awad A.B., Fink C.S., Trautwein E.A., Ntanios F.Y. (2005) J. Nutr. Biochem., 16(11), 650-665. Scholar google search
von Holtz R.L., Fink C.S., Awad A.B. (1998) Nutr. Cancer., 32(1), 8-12. Scholar google search
Awad A.B., Gan Y., Fink C.S. (2000) Nutr. Cancer, 36(1), 74-78. Scholar google search
Awad A.B., Fink C.S., Trautwein E.A., Ntanios F.Y. (2005) J. Nutr. Biochem., 16(11), 650-655. Scholar google search
Awad A.B., Burr A.T., Fink C.S. (2005) Prostaglandins Leukot. Essent. Fatty Acids, 72(3), 219-226. Scholar google search
Choi Y.S., Goto S., Ikeda I., Sugano M. (1989) Lipids, 24(1), 45-50. Scholar google search
Jia X., Ebine N., Wang Y., Awad A.B., Jones P.J. (2006) J. Nutr. Biochem., 17(6), 396-401. Scholar google search
Baginski M., Resat H., Borowski E. (2002) Biochim. Biophys. Acta, 1567(1-2), 63-78. Scholar google search
Onda M., Inoue Y., Kawabata M., Mita T. (2003) J. Biochem. (Tokyo), 134(1), 121-128. Scholar google search
Hac-Wydro K., Dynarowicz-Latka P., Grzybowska J., Borowski E. (2005) Biophys. Chem., 116(1), 77-88. Scholar google search
Mizushina Y., Nakanishi R., Kuriyama I., Kamiya K., Satake T., Shimazaki N., Koiwai O., Uchiyama Y., Yonezawa Y., Takemura M., Sakaguchi K., Yoshida H. (2006) J. Steroid Biochem. Mol. Biol., 99(2-3), 100-107. Scholar google search
Adcox C., Boyd L., Oehrl L., Allen J., Fenner G. (2001) J. Agric. Food Chem., 49(4), 2090-2095. Scholar google search
Plat J., Brzezinka H., Lьtjohann D., Mensink R.P., von Bergmann K. (2001) J. Lipid Res., 42(12), 2030-2038. Scholar google search
Skrede B., Bjorkhem I., Bergesen O., Kayden H.J., Skrede S. (1985) Biochim. Biophys. Acta, 836(3), 368-375. Scholar google search
Lund E., Boberg K.M., Bystrom S., Olund J., Carlstrom K., Bjorkhem I. (1991)J. Biol. Chem., 266(8), 4929-4937. Scholar google search
Boberg K.M., Lund E., Olund J., Bjorkhem I. (1990) J. Biol. Chem., 265(14), 7967-7975. Scholar google search
Boberg K.M, Skrede B., Skrede S. (1986) Scand. J. Clin. Lab. Invest., 184(1), 47-54. Scholar google search
Boberg K.M., Einarsson K., Bjorkhem I. (1990) J. Lipid Res., 31(6), 1083-1088. Scholar google search
Maguire L., Konoplyannikov M., Ford A., Maguire A.R., O`Brien N.M. (2003) Br. J. Nutr., 90(4), 767-775. Scholar google search
Ryan E., Chopra J., McCarthy F., Maguire A.R., O`Brien N.M. (2005) Br. J. Nutr. 94(3), 443-451. Scholar google search
Roussi S., Winter A., Gosse F., Werner D., Zhang X., Marchioni E., Geoffroy P., Miesch M., Raul F. (2005) Cell Death Differ., 12(2), 128-135. Scholar google search
Пийр Е.А.,Морозевич Г.Е., Дроздов Ф.В., Тимофеев В.П., Мишарин А.Ю. (2006) Биоорган. химия, 32(5), 551-558. Scholar google search
Флегентов Г.Ю., Ткачев Я.В., Пийр Е.А., Плешкова А.П., Тимофеев В.П., Мишарин А.Ю. (2005) Биоорган. химия, 31(5), 528-534. Scholar google search
Macias F.A., Chinchilla N., Varela R.M., Molinillo J.M.G. (2006) Steroids, 71(7), 603-608. Scholar google search
Lindequist U., Lesnau A., Teuscher E., Pilgrim H. (1989) Pharmazie, 44(8), 579-580. Scholar google search
Fujimoto H., Nakayama M., Nakayama Y., Yamazaki M. (1994) Chem. Pharm. Bull., 42(5), 694-697. Scholar google search
Yasukawa K., Akihisa T., Kanno H., Kaminaga T., Izumida M., Sakoh T. (1996) Biol. Pharm. Bull., 19(4), 573-576. Scholar google search
Bok J.W., Lermer L., Chilton J., Klingeman H.G., Towers G.H. (1999) Phytochemistry, 51 (7), 891-898. Scholar google search
Mizushina Y., Watanabe I., Togashi H., Hanashima L., Takemura M., Ohta K., Sugawara F., Koshino H., Esumi Y., Uzawa J., Matsukage A., Yoshida S., Sakaguchi K. (1998) Biol. Pharm. Bull., 21(5), 444-448. Scholar google search
Ikeda I., Konno R., Shimizu T., Ide T., Takahashi N., Kawada T., Nagao K., Inoue N., Yanagita T., Hamada T., Morinaga Y., Tomoyori H., Imaizumi K., Suzuki K. (2006) Biochim. Biophys. Acta, 1760(5), 800-807. Scholar google search
Kaneko E., Matsuda M., Yamada Y., Tachibana Y., Shimomura I., Makishima M. (2003) J. Biol. Chem., 278(38), 36091-36098. Scholar google search
Koolman J. (1990) Zoological Sci., 7, 563-580. Scholar google search
Slama K., Lafont R. (1995) Eur. J. Entomol., 92, 355-377. Scholar google search
Володин В.В., Ширшова Т.И., Бурцева С.А., Мельник М.В. (1999) Растительные ресурсы, 2(1), 76-81. Scholar google search
Guo F. (1989) in: Ecdysone - from chemistry to mode of action. (J. Koolman ed.), G. Thieme, Stuttgart, pp. 442-446. Scholar google search
Báthori M. (2002) Mini Rev. Med. Chem., 2, 285-293. Scholar google search
Dinan L., Savchenko T., Whiting P., Sarker S.D. (1999) Pesticide Sci., 55, 331-335. Scholar google search
Dinan L. (2001) Phytochemistry, 57(3), 325-339. Scholar google search
Lafont R., Dinan L. (2003) J. Insect Sci., 3(7), 1-30. (online: insectsci.org) . Scholar google search
Luo Y., Amin J., Voellmy R. (1991) Mol. Cell Biol., 11(7), 3660-3675. Scholar google search
Oro A.E., McKeown M., Evans R.M. (1992) Curr. Opin. Genet. Dev., 2(2), 269-274. Scholar google search
Christopherson K.S., Mark M.R., Bajaj V., Godowski P.J. (1992) Proc. Natl. Acad. Sci. USA, 89(14), 6314-6318. Scholar google search
Mangelsdorf D.J., Evans R.M. (1995) Cell, 83(6), 841-850. Scholar google search
Giguerre V. (1999) Endocrine Rev., 20(5), 689-725. Scholar google search
Palli S.R., Hormann R.E., Schlattner U., Lezzi M. (2005) Vitam Horm., 73, 59-100. Scholar google search
Yao T.P., Segraves W.A., Oro A.E., McKeown M., Evans R.M. (1992) Cell, 71(1), 63-72. Scholar google search
Zelhof A.C., Yao T.P., Evans R.M., McKeown M. (1995) Proc. Natl. Acad. Sci. USA, 92(23), 10477-10481. Scholar google search
Nieva C., Gwozdz T., Dutko-Gwozdz J., Wiedenmann J., Spindler-Barth M., Wieczorek E., Dobrucki J., Dus D., Henrich V., Ozyhar A., Spindler D. (2005) Biol Chem., 386(5), 463-470. Scholar google search
Hannan G.N., Hill R.J. (1997) Insect. Biochem. Mol. Biol., 27(6), 479-488. Scholar google search
Kumar M.B., Fujimoto T., Potter D.W., Deng Q., Palli S.R. (2002) Proc. Natl. Acad. Sci. USA, 99(23) 14710-14715. Scholar google search
Suhr S.T., Gil E.B., Senut M.C., Gage F.H. (1998) Proc. Natl. Acad. Sci. USA, 95(14), 7999-8004. Scholar google search
Hannan G.N., Hill R.J. (2001) Insect Biochem. Mol. Biol., 31(8) 771-781. Scholar google search
Van Craenenbroeck K., Vanhoenacker P, Leysen J.E., Haegeman G. (2001) Eur. J. Neurosci., 14(6), 968-976. Scholar google search
Timmer R.T., Gunn R.B. (1999) Am. J. Physiol., 276(1, 1), 66-75. Scholar google search
Sawicki J.A., Monks B., Morris R.J. (1998) Biotechniques, 25(5), 868-875. Scholar google search
Dunlop J., Lou Z., McIlvain H.B. (1999) Biochem. Biophys. Res. Commun., 265(1), 101-105. Scholar google search
Dunlop J., Lou Z., Zhang Y., McIlvain H.B. (1999) Br. J. Pharmacol., 128(7), 1485-1490. Scholar google search
Rampazzo C., Johansson M., Gallinaro L., Ferraro P., Hellman U., Karlsson A., Reichard P., Bianchi V. (2000) J. Biol. Chem., 275(8), 5409-5415. Scholar google search
Albanese C., Reutens A.T., Bouzahzah B., Fu M., D`Amico M., Link T., Nicholson R., Depinho R.A., Pestell R.G. (2000) FASEB J., 14(7), 877-884. Scholar google search
Wakita K., McCormick F., Tetsu O. (2001) Biotechniques, 31(2), 414-418. Scholar google search
Wyborski D.L., Bauer J.C., Vaillancourt P. (2001) Biotechniques, 31(3), 618-624. Scholar google search
Shi Y., Simmons M.N., Seki T., Oh S.P., Sugrue S.P. (2001) Oncogene, 20(30), 4007-4018. Scholar google search
Stolarov J., Chang K., Reiner A., Rodgers L., Hannon G.J., Wigler M.H., Mittal V. (2001) Proc. Natl. Acad. Sci. USA, 98(23), 13043-13048. Scholar google search
No D., Yao T.P., Evans R.M. (1996) Proc. Natl. Acad. Sci USA, 93(8), 3346-3351. Scholar google search
Saez E., Nelson M.C., Eshelman B., Banayo E., Koder A., Cho G.J., Evans R.M. (2000) Proc. Natl. Acad. Sci USA, 97(26), 14512-14517. Scholar google search
Constantino S., Santos R., Gisselbrecht S., Gouilleux F. (2001) Eur. Cytokine Netw., 12(2), 365-367. Scholar google search
Choi D.S., Wang D., Tolbert L., Sadee W. (2000) J. Neurosci. Methods, 94(2), 217-225. Scholar google search
Oehme I., Bosser S., Zornig M. (2006) Cell Death Differ., 13(2), 189-201. Scholar google search
Baker K.D., Shewchuk L.M., Kozlova T., Makishima M., Hassell A., Wisely B., Caravella J.A., Lambert M.H., Reinking J.L., Krause H., Thummel C.S., Willson T.M., Mangelsdorf D.J. (2003) Cell, 113(6), 731-742. Scholar google search
Кутепова T.A, Сыров В.Н., Хушбактова З.А., Саатов З. (2001) Хим. Фарм. Ж., 35(4), 608-609. Scholar google search
Yang C., Zhang G., Liu X., Wang C. (2001) Appl. CN-2000-10637/20000612 (Chem. Abstr. 135, 127188). Scholar google search
Prete P.E. (1997) Life Sci., 60(8), 505-510. Scholar google search
Koцюруба А.В., Буханевич О.М., Мегед О.Ф., Тараканов С.С., Бердышев А.Г., Туганова А.В. (1999) Укр. Биохим. Ж., 71(1), 27-32. Scholar google search
Trenin D.S., Volodin V.V. (1999) Arch. Insect Biochem. Physiol., 41(3), 156-161. Scholar google search
Schroepfer G.J. (2002) Physiol. Rew., 80(1), 361-554. Scholar google search
Smith L.L. (1992) in: Biological Effects of Cholesterol Oxides (Peng S-K., Morin R.J, eds), CRC, Boca Raton., FL, pp.7-31. Scholar google search
Björkhem I. (2002) J. Clin. Invest., 110(6), 725-730. Scholar google search
Panini S.R., Sinensky M.S. (2001) Cur. Opin. Lipidol., 12(5), 529-538. Scholar google search
Пийр Е.А,. Мишарин А.Ю. (2004) Биол. мембр., 21(4), 273-294. Scholar google search
Björkhem I. (1992) J. Lipid Res., 33(3), 455-471. Scholar google search

2024 (том 70)
2023 (том 69)
2022 (том 68)
2021 (том 67)
2020 (том 66)
2019 (том 65)
2018 (том 64)
2017 (том 63)
2016 (том 62)
2015 (том 61)
2014 (том 60)
2013 (том 59)
2012 (том 58)
2011 (том 57)
2010 (том 56)
2009 (том 55)
2008 (том 54)
2007 (том 53)

Выпуск 6
Выпуск 5
Выпуск 4
Выпуск 3
Выпуск 2
Выпуск 1

2006 (том 52)
2005 (том 51)
2004 (том 50)
2003 (том 49)

◄ ►