G-квадруплексы (G4), представляющие собой неканонические вторичные структуры ДНК, интенсивно исследуются на протяжении длительного времени. У эукариот они играют важную роль в регуляции экспрессии генов и репарации ДНК. G4 также были обнаружены в геномах многочисленных бактерий и архей, однако их функциональная роль окончательно не выяснена. Известно, что G4 учувствуют в формировании антигенной изменчивости, патогенности, антибиотикоустойчивости и выживании в экстремальных условиях. Разработано достаточно много инструментов по обнаружению потенциальных G4 последовательностей и подтверждению их формирования. Поскольку контролируемое образование и разрешение квадруплекса представляет собой важный инструмент регуляции критически значимых для выживания генов, перспективным направлением исследований является поиск лигандов — соединений, способных оказывать на структуру квадруплекса стабилизирующее действие и тем самым останавливать экспрессию генов. В настоящее время уже известен ряд лигандов, применение которых останавливает рост патогенных микроорганизмов. G4-лиганды представляют интерес в качестве потенциальных противомикробных препаратов, что является чрезвычайно актуальным в связи с широким распространением патогенных микроорганизмов с лекарственной устойчивостью.
Шитиков Е.А., Беспятых Д.А., Бодоев И.Н., Зайчикова М.В. (2022) G-квадруплексы у бактерий: функциональная роль и перспективы использования в качестве биомишеней. Биомедицинская химия, 68(2), 93-103.
Шитиков Е.А. и др. G-квадруплексы у бактерий: функциональная роль и перспективы использования в качестве биомишеней // Биомедицинская химия. - 2022. - Т. 68. -N 2. - С. 93-103.
Шитиков Е.А. и др., "G-квадруплексы у бактерий: функциональная роль и перспективы использования в качестве биомишеней." Биомедицинская химия 68.2 (2022): 93-103.
Шитиков, Е. А., Беспятых, Д. А., Бодоев, И. Н., Зайчикова, М. В. (2022). G-квадруплексы у бактерий: функциональная роль и перспективы использования в качестве биомишеней. Биомедицинская химия, 68(2), 93-103.
Переводная версия в журнале «Biomedical Chemistry (Moscow) Supplement Series B»:10.1134/S1990750822040084
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