1. Владивостокский филиал Дальневосточного научного центра физиологии и патологии дыхания — Научно-исследовательский институт медицинской климатологии и восстановительного лечения, Владивосток, Россия
Установление патофизиологических механизмов регуляции процессов воспаления является актуальной проблемой, решение которой позволит уменьшить риск развития большинства социально-значимых заболеваний. Метаболиты полиненасыщенных жирных кислот (ПНЖК) являются ключевыми сигнальными молекулами, контролирующими интенсивность и разрешение воспаления. Открытия последних лет показали, что эпоксиды ПНЖК, образующиеся под действием цитохрома P450 (CYP), обладают противовоспалительными и проразрешающими свойствами. Также показано, что противовоспалительные эффекты ω-3 ПНЖК опосредованы их превращением в эндоканнабиноидные эпоксиды. Механизм противовоспалительного действия эпоксидов ПНЖК направлен на подавление экспрессии транскрипционных ядерных факторов, воспалительных цитокинов, модуляцию экспрессии ионных каналов транзиторного рецепторного потенциала и каннабиноидных рецепторов. Изучение роли эпоксидов ПНЖК в регуляции воспаления и фармакологическое моделирование активности CYP являются многообещающим направлением в разработке новых стратегий лечения воспалительных заболеваний. В настоящем обзоре систематизированы современные литературные данные о метаболизме ПНЖК, эндоканнабиноидов и их эпоксидов, а также ключевых ферментах, участвующих в данных реакциях. Обсуждается роль эпоксидов ПНЖК в регуляции воспаления и перспективы фармакологического влияния на их биосинтез для минимизации воспаления при различных заболеваниях.
Кытикова О.Ю. и др. Эпоксиды полиненасыщенных жирных кислот в регуляции воспаления // Биомедицинская химия. - 2022. - Т. 68. -N 3. - С. 177-189.
Кытикова О.Ю. и др., "Эпоксиды полиненасыщенных жирных кислот в регуляции воспаления." Биомедицинская химия 68.3 (2022): 177-189.
Кытикова, О. Ю., Денисенко, Ю. К., Новгородцева, Т. П., Бочарова, Н. В., Коваленко, И. С. (2022). Эпоксиды полиненасыщенных жирных кислот в регуляции воспаления. Биомедицинская химия, 68(3), 177-189.
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