Зонулин — регуляция плотных контактов в мозге и кишечнике — факты и гипотезы
Нарыжный С.Н.1 , Легина О.К.2
1. Научно-исследовательский институт биомедицинской химии имени В.Н. Ореховича, Москва, Россия; Петербургский институт ядерной физики им. Б.П. Константинова Национального исследовательского центра “Курчатовский институт”, Гатчина, Россия 2. Петербургский институт ядерной физики им. Б.П. Константинова Национального исследовательского центра “Курчатовский институт”, Гатчина, Россия
За последние годы взаимная связь между мозгом и кишечником стала областью большого научного интереса. Кишечник отвечает не только за пищеварение, он содержит миллионы нейронов, собственную иммунную систему и влияет на эмоциональные и когнитивные процессы. Взаимоотношение между кишечником и мозгом предполагает, что процессы, осуществляемые микробиотой кишечника, играют значительную роль в регуляции работы мозга, и наоборот. Особую роль здесь играют межклеточные плотные контакты (ПК, tight junctions, TJ), где важное место занимает белок зонулин. Зонулин — непроцессированный предшественник зрелого гаптоглобина, единственный физиологический модулятор ПК, открытый за последние годы, который может обратимо регулировать проницаемость интестинального (ИБ) и гематоэнцефалического (ГЭБ) барьеров в организме человека. Нарушение ГЭБ и изменённый состав микробиоты связывают со многими заболеваниями, в том числе неврологическими расстройствами и нейровоспалением. То есть, имеется кишечно-мозговая ось (КМО) — коммуникативная система, посредством которой мозг модулирует функции желудочно-кишечного тракта (ЖКТ), и наоборот. В основе КМО лежат нейронные, эндокринные и иммунологические механизмы, связанные друг с другом на организменном, органном, клеточном и молекулярном уровнях.
Нарыжный С.Н., Легина О.К. (2022) Зонулин — регуляция плотных контактов в мозге и кишечнике — факты и гипотезы. Биомедицинская химия, 68(5), 309-320.
Нарыжный С.Н. и др. Зонулин — регуляция плотных контактов в мозге и кишечнике — факты и гипотезы // Биомедицинская химия. - 2022. - Т. 68. -N 5. - С. 309-320.
Нарыжный С.Н. и др., "Зонулин — регуляция плотных контактов в мозге и кишечнике — факты и гипотезы." Биомедицинская химия 68.5 (2022): 309-320.
Нарыжный, С. Н., Легина, О. К. (2022). Зонулин — регуляция плотных контактов в мозге и кишечнике — факты и гипотезы. Биомедицинская химия, 68(5), 309-320.
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