1. Физический факультет МГУ им. М.В. Ломоносова, Москва, Россия; Медицинский факультет, Московский финансово-промышленный университет “Синергия”, Москва, Россия 2. Физический факультет МГУ им. М.В. Ломоносова, Москва, Россия 3. Медицинский институт, Российский университет дружбы народов, Москва, Россия
Рассмотрены основные молекулярно-биологические особенности возбудителя COVID-19 — вируса SARS-CoV-2: его жизненный цикл, пути проникновения вируса в различные клетки, взаимодействие вирусных белков с белками человека, цитопатические эффекты. Проведён анализ патологических состояний, возникающих как в ходе заболевания COVID-19, так и после исчезновения вируса из организма. Приведён краткий обзор биологических активностей полисахаридов, выделенных из различных источников, рассмотрены возможные молекулярно-биологические механизмы этих активностей. Анализ совокупности данных показывает, что полисахариды представляют собой класс соединений, потенциально имеющих перспективы для использования в терапии как острых состояний при COVID-19, так и при постковидном синдроме.
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Ключевые слова: SARS-CoV-2, рецепторы, пути проникновения в клетку, COVID-19, ассоциированные состояния, полисахариды
Цитирование:
Генералов Е.А., Симоненко Е.Ю., Кульченко Н.Г., Яковенко Л.В. (2022) Молекулярные основы биологической активности полисахаридов при ассоциированных с COVID-19 состояниях. Биомедицинская химия, 68(6), 403-418.
Генералов Е.А. и др. Молекулярные основы биологической активности полисахаридов при ассоциированных с COVID-19 состояниях // Биомедицинская химия. - 2022. - Т. 68. -N 6. - С. 403-418.
Генералов Е.А. и др., "Молекулярные основы биологической активности полисахаридов при ассоциированных с COVID-19 состояниях." Биомедицинская химия 68.6 (2022): 403-418.
Генералов, Е. А., Симоненко, Е. Ю., Кульченко, Н. Г., Яковенко, Л. В. (2022). Молекулярные основы биологической активности полисахаридов при ассоциированных с COVID-19 состояниях. Биомедицинская химия, 68(6), 403-418.
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