1. Национальный медицинский исследовательский центр психиатрии и наркологии имени В.П. Сербского Минздрава России, Москва, Россия 2. Институт биологии гена Российской академии наук, 119334, Москва, Россия 3. Институт общей физики им. А.М. Прохорова РАН, Москва, Россия; Национальный исследовательский ядерный университет МИФИ, Москва, Россия
Глиобластома — первичная опухоль головного мозга — является одним из наиболее агрессивных видов злокачественных новообразований. Даже в случае ранней диагностики и при своевременно начатом лечении с помощью современных химиотерапевтических препаратов, лучевой терапии и хирургического лечения прогноз остаётся неблагоприятным с коротким периодом выживания после постановки диагноза. В связи с этим продолжается исследование основных патогенетических звеньев развития глиобластом. В настоящее время основное внимание уделяется исследованию молекулярной характеристики опухолей, включая анализ внеклеточных везикул, которые играют важную роль в процессах межклеточной коммуникации. В настоящем обзоре с целью освещения актуальной информации о роли внеклеточных везикул в диагностике и терапии глиом проведён анализ накопленных результатов российских и зарубежных исследований, связанных с данным направлением. Основной задачей данной работы было рассмотрение особенностей внеклеточных везикул как контейнеров и переносчиков глиомных маркеров, а также нуклеиновых кислот, используемых в диагностике и терапии.
Филин А.А., Чернышева А.А., Павлова Г.В., Лощенов В.Б., Гурина О.И. (2022) Внеклеточные везикулы в диагностике и терапии глиом: проблемы и перспективы. Биомедицинская химия, 68(6), 419-426.
Филин А.А. и др. Внеклеточные везикулы в диагностике и терапии глиом: проблемы и перспективы // Биомедицинская химия. - 2022. - Т. 68. -N 6. - С. 419-426.
Филин А.А. и др., "Внеклеточные везикулы в диагностике и терапии глиом: проблемы и перспективы." Биомедицинская химия 68.6 (2022): 419-426.
Филин, А. А., Чернышева, А. А., Павлова, Г. В., Лощенов, В. Б., Гурина, О. И. (2022). Внеклеточные везикулы в диагностике и терапии глиом: проблемы и перспективы. Биомедицинская химия, 68(6), 419-426.
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