ДНК-полимеразы β обеспечивают репарацию повреждённой ДНК. В клетках злокачественных опухолей происходит изменение продукции и свойств этих ферментов, что сопровождается нарушением жизнеспособности опухолевых клеток. Анализ результатов исследований, опубликованных в российских и международных базах данных (Pubmed, Elsevier), касающихся структуры и свойств ДНК-полимераз β и их роли в росте и пролиферации клеток, показал, что в клетках ряда злокачественных опухолей имеет место гиперэкспрессия генов β-подобных ДНК-полимераз. Это в значительной мере обеспечивает поддержание их жизнеспособности и пролиферативной активности. Направленное ингибирование β-подобных ДНК-полимераз сопровождается возникновением антипролиферативного и противоопухолевого эффекта. В качестве перспективных противоопухолевых фармакофоров могут быть использованы соединения стабильного парамагнитного изотопа магния (25Mg2+) или других, обладающих некомпенсированным ядерным спином изотопов, дивалентных металлов (43Ca2+ и 67Zn2+), а также короткие одноцепочечные полидезоксирибонуклеотиды.
Давыдов В.В., Бухвостов А.А., Кузнецов Д.А. (2023) β-Подобные ДНК-полимеразы и перспективы их использования в качестве мишеней в химиотерапии опухолей. Биомедицинская химия, 69(3), 145-155.
Давыдов В.В. и др. β-Подобные ДНК-полимеразы и перспективы их использования в качестве мишеней в химиотерапии опухолей // Биомедицинская химия. - 2023. - Т. 69. -N 3. - С. 145-155.
Давыдов В.В. и др., "β-Подобные ДНК-полимеразы и перспективы их использования в качестве мишеней в химиотерапии опухолей." Биомедицинская химия 69.3 (2023): 145-155.
Давыдов, В. В., Бухвостов, А. А., Кузнецов, Д. А. (2023). β-Подобные ДНК-полимеразы и перспективы их использования в качестве мишеней в химиотерапии опухолей. Биомедицинская химия, 69(3), 145-155.
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