Поиск и создание инновационных антимикробных препаратов, действующих в отношении резистентных и полирезистентных штаммов бактерий и грибов, является одной из важнейших задач современной биоорганической химии и фармацевтики. Поскольку железо необходимо для жизнедеятельности практически всех организмов, включая млекопитающих и бактерий, белки, участвующие в его обмене, могут служить в качестве потенциальных мишеней при создании новых перспективных антимикробных агентов. К таким мишеням относятся эндогенные биомолекулы млекопитающих — гемоксигеназы, сидерофоры, белок 24p3, — а также гемоксигеназы и сидерофоры бактерий. Определённый интерес представляют и другие белки, которые ответственны за доставку железа в клетки и его баланс между бактериями и организмом хозяина. В обзоре обобщены данные по созданию ингибиторов и индукторов (активаторов) гемоксигеназ, селективных для млекопитающих и бактерий, обсуждаются особенности их механизмов действия и строения. На основании рассмотренных литературных данных сделан вывод о перспективности использования гемина — самого мощного индуктора гемоксигеназы — и его производных в качестве потенциальных антимикробных и противовирусных агентов, в частности против COVID-19 и других опасных инфекций. При этом важная роль отводится продуктам деградации гемина под действием гемоксигеназ, в том числе in vivo. Определённое внимание уделено данным по антимикробному действию не содержащих железа протопорфиринатов, а именно комплексов с Co, Ga, Zn, Mn, их преимуществам и недостаткам по сравнению с гемином. Модификация известного антибиотика цефтазидима молекулой сидерофора повысила эффективность его действия против резистентных бактерий.
Благодаров С.В., Желтухина Г.А., Небольсин В.Е. (2023) Обмен железа в клетке как мишень при создании потенциальных антимикробных и противовирусных средств. Биомедицинская химия, 69(4), 199-218.
Благодаров С.В. и др. Обмен железа в клетке как мишень при создании потенциальных антимикробных и противовирусных средств // Биомедицинская химия. - 2023. - Т. 69. -N 4. - С. 199-218.
Благодаров С.В. и др., "Обмен железа в клетке как мишень при создании потенциальных антимикробных и противовирусных средств." Биомедицинская химия 69.4 (2023): 199-218.
Благодаров, С. В., Желтухина, Г. А., Небольсин, В. Е. (2023). Обмен железа в клетке как мишень при создании потенциальных антимикробных и противовирусных средств. Биомедицинская химия, 69(4), 199-218.
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