1. Национальный научный центр наркологии — филиал Национального медицинского исследовательского центра психиатрии и наркологии им. В.П. Сербского, Москва, Россия 2. Научный центр биомедицинских технологий, Светлые горы, Московская область, Россия
Аффективная патология (тревога, депрессия) у взрослого потомства матерей, употреблявших алкоголь во время беременности, может быть связана с изменением баланса нейроиммунных факторов в миндалине мозга (corpus amygdaloideum) и, как следствие, нарушением её функций в процессинге эмоционально значимых стимулов. Целью исследования было изучение содержания цитокинов TNF-α, IL-1α, IL-1β, IL-10 и IL-17 в миндалине мозга взрослых пренатально алкоголизированных и контрольных самок крыс. Для количественной оценки содержания целевых цитокинов был использован мультиплексный иммунофлуоресцентный анализ. Уровень экспрессии мРНК анализировали методом ПЦР в режиме реального времени после обратной транскрипции. Увеличение содержания провоспалительных цитокинов TNF-α и IL-1β в миндалине взрослых пренатально алкоголизированных животных не было связано с изменением уровня экспрессии мРНК. Наши данные свидетельствуют о том, что воздействие этанола на плод во время беременности может приводить к долгосрочным изменениям содержания ключевых провоспалительных цитокинов в миндалине, которые, в свою очередь, выступают фактором риска аффективных патологий в позднем возрасте.
Кохан В.С., Анохин П.К., Проскурякова Т.В., Шохонова В.А., Агельдинов Р.А., Шамакина И.Ю. (2023) Интерлейкин-1β и TNF-α повышены в миндалине пренатально алкоголизированных взрослых крыс. Биомедицинская химия, 69(5), 300-306.
Кохан В.С. и др. Интерлейкин-1β и TNF-α повышены в миндалине пренатально алкоголизированных взрослых крыс // Биомедицинская химия. - 2023. - Т. 69. -N 5. - С. 300-306.
Кохан В.С. и др., "Интерлейкин-1β и TNF-α повышены в миндалине пренатально алкоголизированных взрослых крыс." Биомедицинская химия 69.5 (2023): 300-306.
Кохан, В. С., Анохин, П. К., Проскурякова, Т. В., Шохонова, В. А., Агельдинов, Р. А., Шамакина, И. Ю. (2023). Интерлейкин-1β и TNF-α повышены в миндалине пренатально алкоголизированных взрослых крыс. Биомедицинская химия, 69(5), 300-306.
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