Проблемы и перспективы поиска новых фармакологических средств для лечения сердечно-сосудистых заболеваний среди агонистов, антагонистов и аллостерических модуляторов аденозиновых рецепторов
Перфилова В.Н.1, Музыко Е.А.2 , Таран А.С.2, Шевченко А.А.2, Науменко Л.В.2
1. Волгоградский государственный медицинский университет, Волгоград, Россия; Волгоградский медицинский научный центр, Волгоград, Россия 2. Волгоградский государственный медицинский университет, Волгоград, Россия
А1-аденозиновые рецепторы широко распространены в организме человека и опосредуют множество разнообразных эффектов. Значительное их количество представлено в сердечно-сосудистой системе, где они контролируют ангиогенез, тонус сосудов, частоту сердечных сокращений и проводимость, что делает этот подтип рецепторов перспективной мишенью для терапии сердечно-сосудистых заболеваний. В обзоре обобщены литературные данные о строении и функционировании А1-аденозиновых рецепторов, проанализировано их участие в формировании гипертрофии миокарда, его ишемически-реперфузионного повреждения, различных видов нарушений сердечного ритма, хронической сердечной недостаточности, артериальной гипертензии. Рассмотрена роль и некоторых аллостерических регуляторов А1-аденозиновых рецепторов в качестве потенциальных средств для терапии заболеваний сердечно-сосудистой системы.
Перфилова В.Н., Музыко Е.А., Таран А.С., Шевченко А.А., Науменко Л.В. (2023) Проблемы и перспективы поиска новых фармакологических средств для лечения сердечно-сосудистых заболеваний среди агонистов, антагонистов и аллостерических модуляторов аденозиновых рецепторов. Биомедицинская химия, 69(6), 353-370.
Перфилова В.Н. и др. Проблемы и перспективы поиска новых фармакологических средств для лечения сердечно-сосудистых заболеваний среди агонистов, антагонистов и аллостерических модуляторов аденозиновых рецепторов // Биомедицинская химия. - 2023. - Т. 69. -N 6. - С. 353-370.
Перфилова В.Н. и др., "Проблемы и перспективы поиска новых фармакологических средств для лечения сердечно-сосудистых заболеваний среди агонистов, антагонистов и аллостерических модуляторов аденозиновых рецепторов." Биомедицинская химия 69.6 (2023): 353-370.
Перфилова, В. Н., Музыко, Е. А., Таран, А. С., Шевченко, А. А., Науменко, Л. В. (2023). Проблемы и перспективы поиска новых фармакологических средств для лечения сердечно-сосудистых заболеваний среди агонистов, антагонистов и аллостерических модуляторов аденозиновых рецепторов. Биомедицинская химия, 69(6), 353-370.
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