Реналаза (RNLS) — недавно открытый белок, который играет важную роль в регуляции артериального давления, действуя внутри и снаружи клеток. Внутриклеточная RNLS — FAD-зависимая оксидоредуктаза, которая осуществляет окисление изомерных форм β-NAD(P)H. Внеклеточная реналаза, лишённая своего N-концевого пептида и кофактора FAD, проявляет различные защитные эффекты при помощи некаталитических механизмов. По данным ряда авторов, пептид RP220 (20-членный пептид, соответствующий аминокислотной последовательности RNLS 220–239) воспроизводит ряд некаталитических эффектов этого белка, действуя на рецепторные белки плазматической мембраны. Возможность взаимодействия этого пептида с внутриклеточными белками не изучена. С учётом известной роли RNLS как возможного антигипертензивного фактора, в данной работе осуществлено протеомное профилирование почек нормо- и гипертензивных крыс с использованием RP220 в качестве аффинного лиганда. Протеомная (полуколичественная) идентификация выявила изменения относительного содержания связавшихся с аффинным сорбентом около 200 индивидуальных белков почек гипертензивных крыс по сравнению с почками нормотензивных животных. При этом оказалось, что связавшиеся с RP220 белки, для которых обнаружено наиболее выраженное увеличение относительного содержания у гипертензивных животных по сравнению с нормотензивными, вовлечены в развитие сердечно-сосудистой патологии. Снижение связывания с RP220 белков почек гипертензивных животных отмечено для компонентов убиквитин-протеасомной системы, рибосом и цитоскелета.
Бунеева О.А., Федченко В.И., Калошина С.А., Завьялова М.Г., Згода В.Г., Медведев А.Е. (2024) Протеомное профилирование почек нормо- и гипертензивных крыс с использованием реналазного пептида RP220 в качестве аффинного лиганда. Биомедицинская химия, 70(3), 145-155.
Бунеева О.А. и др. Протеомное профилирование почек нормо- и гипертензивных крыс с использованием реналазного пептида RP220 в качестве аффинного лиганда // Биомедицинская химия. - 2024. - Т. 70. -N 3. - С. 145-155.
Бунеева О.А. и др., "Протеомное профилирование почек нормо- и гипертензивных крыс с использованием реналазного пептида RP220 в качестве аффинного лиганда." Биомедицинская химия 70.3 (2024): 145-155.
Бунеева, О. А., Федченко, В. И., Калошина, С. А., Завьялова, М. Г., Згода, В. Г., Медведев, А. Е. (2024). Протеомное профилирование почек нормо- и гипертензивных крыс с использованием реналазного пептида RP220 в качестве аффинного лиганда. Биомедицинская химия, 70(3), 145-155.
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