Дисфункция эндотелия лежит в основе патогенеза многих заболеваний, прежде всего сердечно-сосудистых. Эпидемиологическими исследованиями показана обратная зависимость между уровнем в плазме крови липопротеинов высокой плотности (ЛПВП) и сердечно-сосудистыми заболеваниями. Результаты экспериментальных исследований свидетельствуют о том, что антиатерогенное действие ЛПВП связано не только с их участием в обратном транспорте избытка холестерина, но и с их регуляторным влиянием на функции клеток различных органов и тканей, в том числе эндотелиальных клеток. Цель настоящего обзора — представить новые данные об участии плазматических рецепторов и связанных с ними внутриклеточных сигнальных путей в механизме защитного действия ЛПВП на функции эндотелиальных клеток. Понимание механизмов регуляции функций клеток под влиянием ЛПВП является важным этапом для разработки новых способов фармакологической коррекции дисфункции эндотелия и создания эффективных эндотелиопротекторных средств.
Потеряева О.Н., Усынин И.Ф. (2024) Молекулярные механизмы регуляторного действия липопротеинов высокой плотности на функции эндотелия. Биомедицинская химия, 70(4), 206-217.
Потеряева О.Н. и др. Молекулярные механизмы регуляторного действия липопротеинов высокой плотности на функции эндотелия // Биомедицинская химия. - 2024. - Т. 70. -N 4. - С. 206-217.
Потеряева О.Н. и др., "Молекулярные механизмы регуляторного действия липопротеинов высокой плотности на функции эндотелия." Биомедицинская химия 70.4 (2024): 206-217.
Потеряева, О. Н., Усынин, И. Ф. (2024). Молекулярные механизмы регуляторного действия липопротеинов высокой плотности на функции эндотелия. Биомедицинская химия, 70(4), 206-217.
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