Хронобиотики: классификации существующих модуляторов циркадных ритмов, перспективы на будущее
Соловьёв И.А.1 , Голубев Д.А.1
1. Сыктывкарский государственный университет имени Питирима Сорокина, Медицинский институт, научно-исследовательская лаборатория “Трансляционная биоинформатика и системная биология”, Сыктывкар, Россия
В обзоре рассматриваются последние достижения фармакологии в контексте перспективы использования хронобиотиков для контроля циркадных ритмов с учётом механизмов действия, классификации и влияния на биологические часы клетки. Хронобиотики выделяются как разнородная группа соединений, способных восстанавливать циркадные ритмы, нарушенные, например, в результате посменной работы или воздействия искусственного света, либо старения организма. В обзоре приведены классификации хронобиотиков по их фармакологическим эффектам, молекулярным мишеням и химической структуре, подчёркивается способность хронобиотиков усиливать или ингибировать ключевые компоненты циркадных часов, такие как белки CLOCK, BMAL1, PER и CRY. Особое внимание уделяется терапевтическому применению хронобиотиков, включая их потенциал для лечения нарушений сна, метаболических и возрастных десинхронозов. Обладая высокой чувствительностью и специфичностью, эти соединения являются перспективными инструментами поддержания физиологических ритмов, обеспечивающими здоровое старение и персонализированный подход к пациенту с нарушениями сна. Учитывая широкий потенциал для репозиционирования соединений, хронобиотики — перспективное направление, в том числе для внедрения экспериментальных соединений-корректоров циркадных ритмов в клиническую практику.
Соловьёв И.А., Голубев Д.А. (2024) Хронобиотики: классификации существующих модуляторов циркадных ритмов, перспективы на будущее. Биомедицинская химия, 70(6), 381-393.
Соловьёв И.А. и др. Хронобиотики: классификации существующих модуляторов циркадных ритмов, перспективы на будущее // Биомедицинская химия. - 2024. - Т. 70. -N 6. - С. 381-393.
Соловьёв И.А. и др., "Хронобиотики: классификации существующих модуляторов циркадных ритмов, перспективы на будущее." Биомедицинская химия 70.6 (2024): 381-393.
Соловьёв, И. А., Голубев, Д. А. (2024). Хронобиотики: классификации существующих модуляторов циркадных ритмов, перспективы на будущее. Биомедицинская химия, 70(6), 381-393.
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