1. Волгоградский государственный медицинский университет, Волгоград, Россия 2. Волгоградский государственный медицинский университет, Волгоград, Россия; Волгоградский медицинский научный центр, Волгоград, Россия 3. Городская клиническая больница им. С.П. Боткина, Москва, Россия
Ген PPM1D и его белковый продукт (серин-треониновая протеинфосфатаза, PPM1D или Wip1) принимают участие в регуляции ответов клетки на повреждение ДНК, контроле клеточного цикла и репарации. Амплификация, сверхэкспрессия или мутации гена PPM1D приводят к изменению реакции клетки на воздействие стрессовых факторов и генетической нестабильности. Нарушаются процессы восстановления двухцепочечных разрывов, эксцизионная репарация нуклеотидов и эксцизионное восстановление азотистых оснований, клеточный цикл и апоптоз. PPM1D путём дефосфорилирования инактивирует белок p53, белки, реагирующие на нарушение целостности цепей ДНК, белки контрольных точек клеточного цикла, апоптотические белки. Это способствует развитию опухоли, её росту и сохранению опухолевого фенотипа. В обзоре представлены данные о роли гена PPM1D в формировании и поддержании различных онкологических процессов — опухолей молочных желез, яичников, предстательной железы, пищевода, желудка, кишечника, печени и поджелудочной железы, гемобластозов и других.
Кучерявенко А.С. и др. Роль гена PPM1D в патогенезе опухолей // Биомедицинская химия. - 2025. - Т. 71. -N 1. - С. 19-28.
Кучерявенко А.С. и др., "Роль гена PPM1D в патогенезе опухолей." Биомедицинская химия 71.1 (2025): 19-28.
Кучерявенко, А. С., Музыко, Е. А., Перфилова, В. Н., Капланов, К. Д., Фролов, М. Ю. (2025). Роль гена PPM1D в патогенезе опухолей. Биомедицинская химия, 71(1), 19-28.
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