Проведён сравнительный анализ белков кератиноцитов НаСаТ в ответ на воздействие субтоксических доз (5 Дж/см² и 25 Дж/см²) ультрафиолетового излучения типа А (UVA). По двум и более уникальным пептидам было идентифицировано 930 белков. На долю белков, относительное содержание которых увеличивалось в кератиноцитах НаСаТ в ответ на облучение кумулятивной дозой 5 Дж/см² не менее, чем в 2 раза, пришлось более половины (54,5%) всех идентифицированных белков. Снижение относительного содержания отмечено всего для 4 белков. Облучение кератиноцитов кумулятивной дозой 25 Дж/см² привело к снижению доли белков (43,0%) с повышенным уровнем регуляции и увеличению количества белков (84) с пониженным уровнем регуляции. Среди белков, относительное содержание которых в кератиноцитах НаСаТ увеличивалось наиболее сильно, были белки, ассоциированные с процессом “клеточной подвижности” (GO: 0048870 — Cell motility), вовлечённые в процесс регуляции формы и размеров клеток, морфогенеза клеток и ремоделирования кожи.
Кисриева Ю.С., Саменкова Н.Ф., Болоченков Н.А., Русанов А.Л., Ромашин Д.Д., Соловьева Н.А., Карузина И.И., Лисица А.В., Петушкова Н.А. (2025) Изменение профиля белков клеточной подвижности в ответ на экспозицию UVA кератиноцитов HaCaT. Биомедицинская химия, 71(2), 146-157.
Кисриева Ю.С. и др. Изменение профиля белков клеточной подвижности в ответ на экспозицию UVA кератиноцитов HaCaT // Биомедицинская химия. - 2025. - Т. 71. -N 2. - С. 146-157.
Кисриева Ю.С. и др., "Изменение профиля белков клеточной подвижности в ответ на экспозицию UVA кератиноцитов HaCaT." Биомедицинская химия 71.2 (2025): 146-157.
Кисриева, Ю. С., Саменкова, Н. Ф., Болоченков, Н. А., Русанов, А. Л., Ромашин, Д. Д., Соловьева, Н. А., Карузина, И. И., Лисица, А. В., Петушкова, Н. А. (2025). Изменение профиля белков клеточной подвижности в ответ на экспозицию UVA кератиноцитов HaCaT. Биомедицинская химия, 71(2), 146-157.
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