Суммированы аргументы, обосновывающие связь ряда заболеваний с альтерацией (перерождением) кишечного микробиома. Приведены основные установленные метаболиты микробного происхождения, которые являются средством коммуникации между микробиомом и организмом хозяина: короткоцепочечные жирные кислоты, желчные кислоты, амины, аминокислоты и их метаболиты. Особое внимание уделено метаболомным исследованиям микробиома при хронических болезнях почек, в частности, иммуноглобулин А-нефропатии. Обоснована правомерность концепции микробиома крови, ранее считавшейся исключительно стерильной средой у здорового человека. Отмечена ключевая роль метагеномных методов для характеристики как состава, так и потенциальных физиологических эффектов микробных сообществ. Проанализированы преимущества и ограничения метаболомного анализа сыворотки/плазмы крови и фекалий. Ввиду того, что потенциал клинических исследований взаимного влияния микробиом–метаболом ограничен генетическими и внешними факторами, сохраняют актуальность доклинические исследования с использованием как безмикробных моделей, так и моделей, основанных на воздействии антибиотиков. В обзоре рассмотрены проблемы и перспективы метаболомики при исследовании характера и механизмов взаимного влияния микробиома и метаболома.
Савельева Е.И., Шачнева М.Д. (2025) Проблемы и перспективы метаболомных исследований при альтерации кишечного микробиома. Биомедицинская химия, 71(3), 195-208.
Савельева Е.И. и др. Проблемы и перспективы метаболомных исследований при альтерации кишечного микробиома // Биомедицинская химия. - 2025. - Т. 71. -N 3. - С. 195-208.
Савельева Е.И. и др., "Проблемы и перспективы метаболомных исследований при альтерации кишечного микробиома." Биомедицинская химия 71.3 (2025): 195-208.
Савельева, Е. И., Шачнева, М. Д. (2025). Проблемы и перспективы метаболомных исследований при альтерации кишечного микробиома. Биомедицинская химия, 71(3), 195-208.
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