1. Белорусский государственный медицинский университет, Минск, Беларусь 2. Республиканский научно-практический центр пульмонологии и фтизиатрии, Минск, Беларусь
Хроническая обструктивная болезнь лёгких (ХОБЛ) является одной из самых распространённых патологий дыхательной системы, которая характеризуется нарастающим ограничением воздушного потока. Течение ХОБЛ нестабильно и нередко сопровождается периодами обострения, когда респираторные симптомы заболевания существенно усиливаются. Частота обострений ХОБЛ является важным предиктором её течения, позволяющим прогнозировать снижение функции лёгочной ткани и исход заболевания. В настоящее время оценка риска будущих обострений ХОБЛ у пациента осуществляется на основании истории предыдущих обострений, а об улучшении его состояния судят на основании ослабления симптомов ХОБЛ. Отсутствие объективных критериев не позволяет однозначно судить о вероятности развития острых состояний и эффективности лечения пациентов с ХОБЛ. На основании анализа литературных данных сделан вывод о потенциальной информативности определения с этой целью уровня хемокинов (CXCL5, CXCL8, CXCR1/2, CD44v6), HIF-1α, прокальцитонина, альбумина и C-реактивного белка, клеток лейкоцитарного ряда, а также их возможной комбинации в периферической крови пациентов с ХОБЛ.
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Ключевые слова: ХОБЛ, биомаркеры, CXCL5, CXCL8, CXCR1/2, CD44v6, HIF-1α, белки острой фазы воспаления, клетки крови
Цитирование:
Мурашко Д.И., Таганович А.Д., Ковганко Н.Н., Никитина И.А., Колб А.В., Богуш Л.С., Давидовская Е.И., Будник О.А. (2025) Прогнозирование течения хронической обструктивной болезни лёгких с использованием биомаркеров в крови. Биомедицинская химия, 71(4), 256-269.
Мурашко Д.И. и др. Прогнозирование течения хронической обструктивной болезни лёгких с использованием биомаркеров в крови // Биомедицинская химия. - 2025. - Т. 71. -N 4. - С. 256-269.
Мурашко Д.И. и др., "Прогнозирование течения хронической обструктивной болезни лёгких с использованием биомаркеров в крови." Биомедицинская химия 71.4 (2025): 256-269.
Мурашко, Д. И., Таганович, А. Д., Ковганко, Н. Н., Никитина, И. А., Колб, А. В., Богуш, Л. С., Давидовская, Е. И., Будник, О. А. (2025). Прогнозирование течения хронической обструктивной болезни лёгких с использованием биомаркеров в крови. Биомедицинская химия, 71(4), 256-269.
Список литературы
Agarwal A.K., Raja A., Brown B.D. (2025) Chronic obstructive pulmonary disease. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; Retrieved April 9, 2025, from: https://pubmed.ncbi.nlm.nih.gov/32644707/. Scholar google search
WHO: the top 10 causes of death. Retrieved April 9, 2025, from: https://www.who.int/news-room/fact-sheets/detail/ the-top-10-causes-of-death. Scholar google search
Simiao C., Kuhn M., Prettner K., Yu F., Yang T., Bärnighausen T., Bloom D., Wang C. (2023) The global economic burden of chronic obstructive pulmonary disease for 204 countries and territories in 2020–50: a health-augmented macroeconomic modelling study. Lancet Global Health, 11(8), e1183–e1193. CrossRef Scholar google search
Adeloye D., Agarwal D., Barnes P.J., Bonay M., van Boven J.F., Bryant J., Caramori G., Dockrell D., d'Urzo A., Ekström M., Erhabor G., Esteban C., Greene C.M., Hurst J., Juvekar S., Khoo E.M., Ko F.W., Lipworth B., López-Campos J.L., Maddocks M., Mannino D.M., Martinez F.J., Martinez-Garcia M.A., McNamara R.J., Miravitlles M., Pinnock H., Pooler A., Quint J.K., Schwarz P., Slavich G.M., Song P., Tai A., Watz H., Wedzicha J.A., Williams M.C., Campbell H., Sheikh A., Rudan I. (2021) Research priorities to address the global burden of chronic obstructive pulmonary disease (COPD) in the next decade. J. Global Health, 11, 15003. CrossRef Scholar google search
Agusti A., Celli B.R., Criner G.J., Halpin D., Anzueto A., Barnes P., Bourbeau J., Han M.K., Martinez F.J., Montes de Oca M., Mortimer K., Papi A., Pavord I., Roche N., Salvi S., Sin D.D., Singh D., Stockley R., López Varela M.V., Wedzicha J.A., Vogelmeier C.F. (2023) Global initiative for chronic obstructive lung disease 2023 report: GOLD executive summary. Eur. Respir. J., 61(4), 2300239. CrossRef Scholar google search
MacLeod M., Papi A., Contoli M., Beghé B., Celli B.R., Wedzicha J.A., Fabbri L.M. (2021) Chronic obstructive pulmonary disease exacerbation fundamentals: diagnosis, treatment, prevention and disease impact. Respirology, 26(6), 532–551. CrossRef Scholar google search
COPD Stages and the GOLD Criteria. Retrieved April 9, 2025, from: https://www.webmd.com/lung/copd/gold-criteria-for-copd. Scholar google search
Celli B.R., Fabbri L.M., Aaron S.D., Agusti A., Brook R.D., Criner G.J., Franssen F.M.E., Humbert M., Hurst J.R., Montes de Oca M., Pantoni L., Papi A., Rodriguez-Roisin R., Sethi S., Stolz D., Torres A., Vogelmeier C.F., Wedzicha J.A. (2023) Differential diagnosis of suspected chronic obstructive pulmonary disease exacerbations in the acute care setting: best practice. Am. J. Respir. Crit. Care Med., 207(9), 1134–1144. CrossRef Scholar google search
Barnes P.J. (2009) The cytokine network in chronic obstructive pulmonary disease. Am. J. Respir. Cells Mol. Biol., 41(6), 631–638. CrossRef Scholar google search
Hurst J.R., Han M.K, Singh B., Sharma S., Kaur G., de Nigris E., Holmgren U., Siddiqui M.K. (2022) Prognostic risk factors for moderate-to-severe exacerbations in patients with chronic obstructive pulmonary disease: a systematic literature review. Respir. Res., 23(1), 213. CrossRef Scholar google search
Müllerová H., Shukla A., Hawkins A., Quint J. (2014) Risk factors for acute exacerbations of COPD in a primary care population: a retrospective observational cohort study. BMJ Open, 4(12), e006171. CrossRef Scholar google search
Kim V., Aaron S.D. (2018) What is a COPD exacerbation? Current definitions, pitfalls, challenges and opportunities for improvement. Eur. Respir. J., 52(5), 1801261. CrossRef Scholar google search
Franciosi L.G., Page C.P., Celli B.R., Cazzola M., Walker M.J., Danhof M., Rabe K.F., Della Pasqua O.E. (2006) Markers of exacerbation severity in chronic obstructive pulmonary disease. Respir. Res., 7(1), 74. CrossRef Scholar google search
Duvoix A., Dickens J., Haq I., Mannino D., Miller B., Tal-Singer R., Lomas D.A. (2013) Blood fibrinogen as a biomarker of chronic obstructive pulmonary disease. Thorax, 68(7), 670–676. CrossRef Scholar google search
Altuntaş E., Turgut T., İlhan N., Deveci F., Muz M.H., Çelik İ. (2003) The levels of oxidant and antioxidant in patients with COPD. Tüberküloz ve Toraks, 51(4), 373–379. Scholar google search
Donnelly L.E., Barnes P.J. (2006) Chemokine receptors as therapeutic targets in chronic obstructive pulmonary disease. Trends Pharmacol. Sci., 27(10), 546–553. CrossRef Scholar google search
Barnes P.J. (2022) Oxidative stress in chronic obstructive pulmonary disease. Antioxidants (Basel), 11(5), 965. CrossRef Scholar google search
Singh D. (2015) Chronic obstructive pulmonary disease, neutrophils and bacterial infection: a complex web involving IL-17 and IL-22 unravels. EBioMedicine, 2(11), 1580–1581. CrossRef Scholar google search
Yoon E.C., Koo S.-M., Park H.Y., Kim H.C., Kim W.J., Kim K.U., Jung K.-S., Yoo K.H., Yoon H.K., Yoon H.-Y. (2024) Predictive role of white blood cell differential count for the development of acute exacerbation in Korean chronic obstructive pulmonary disease. Int. J. Chron. Obstruct. Pulmon. Dis., 19, 17–31. CrossRef Scholar google search
Lonergan M., Dicker A.J., Crichton M.L., Keir H.R., van Dyke M.K., Mullerova H., Miller B.E., Tal-Singer R., Chalmers J.D. (2020) Blood neutrophil counts are associated with exacerbation frequency and mortality in COPD. Respir. Res., 21(1), 166. CrossRef Scholar google search
Song M., Graubard B.I., Loftfield E., Rabkin C.S., Engels E.A. (2024) White blood cell count, neutrophil-to-lymphocyte ratio, and incident cancer in the UK Biobank. Cancer Epidemiol. Biomarkers Prev., 33(6), 821–829. CrossRef Scholar google search
David B., Bafadhel M., Koenderman L., de Soyza A. (2021) Eosinophilic inflammation in COPD: from an inflammatory marker to a treatable trait. Thorax, 76(2), 188–195. CrossRef Scholar google search
Higham A., Beech A., Singh D. (2024) The relevance of eosinophils in chronic obstructive pulmonary disease: inflammation, microbiome, and clinical outcomes. J. Leukoc. Biol., 116(5), 927–946. CrossRef Scholar google search
Kolsum U., Southworth T., Jackson N., Singh D. (2019) Blood eosinophil counts in COPD patients compared to controls. Eur. Respir. J., 54(4), 1900633. CrossRef Scholar google search
Singh D., Kolsum U., Brightling C.E., Locantore N., Agusti A., Tal-Singer R. (2014) Eosinophilic inflammation in COPD: prevalence and clinical characteristics. Eur. Respir. J., 44(6), 1697–1700. CrossRef Scholar google search
Jabarkhil A., Moberg M., Janner J., Petersen M.N., Jensen C.B., Henrik Äangquist L., Vestbo J., Jess T., Porsbjerg C. (2020) Elevated blood eosinophils in acute COPD exacerbations: better short- and long-term prognosis. Eur. Clin. Respir. J., 7(1), 1757274. CrossRef Scholar google search
Singh D. (2020) Blood eosinophil counts in chronic obstructive pulmonary disease: a biomarker of inhaled corticosteroid effects Tuberc. Respir. Dis. (Seoul), 83(3), 185–194. CrossRef Scholar google search
Chapman K.R., Hurst J.R., Frent S.-M., Larbig M., Fogel R., Guerin T., Banerji D., Patalano F., Goyal P., Pfister P., Kostikas K., Wedzicha J.A. (2018) Long-term triple therapy de-escalation to indacaterol/glycopyrronium in patients with chronic obstructive pulmonary disease (SUNSET): a randomized, double-blind, triple-dummy clinical trial. Am. J. Respir. Crit. Care Med., 198(3), 329–339. CrossRef Scholar google search
Jordan A., Sivapalan P., Rømer V., Jensen J.-U. (2023) Time-updated phenotypic guidance of corticosteroids and antibiotics in COPD: rationale, perspective and a proposed method. Biomedicines, 11(5), 1395. CrossRef Scholar google search
Ellingsen J., Janson C., Bröms K., Lisspers K., Ställberg B., Högman M., Malinovschi A. (2021) Neutrophil-to-lymphocyte ratio, blood eosinophils and COPD exacerbations: a cohort study. ERJ Open Res., 7(4), 00471-2021. CrossRef Scholar google search
Fahy J.V. (2015) Type 2 inflammation in asthma — present in most, absent in many. Nat. Rev. Immunol., 15(1), 57–65. CrossRef Scholar google search
Biswas M., Suvarna R., Krishnan S.V., Devasia T., Shenoy Belle V., Prabhu K. (2022) The mechanistic role of neutrophil lymphocyte ratio perturbations in the leading non communicable lifestyle diseases. F1000Research, 11, 960. CrossRef Scholar google search
Semenzato U., Biondini D., Bazzan E., Tiné M., Balestro E., Buldini B., Carizzo S.J., Cubero P., Marin-Oto M., Casara A., Baraldo S., Turato G., Gregori D., Marin J.M., Cosio M.G., Saetta M. (2021) Low-blood lymphocyte number and lymphocyte decline as key factors in copd outcomes: a longitudinal cohort study. Respiration, 100(7), 618–630. CrossRef Scholar google search
Moon S.W., Leem A.Y., Kim Y.S., Lee J.-H., Kim T.-H., Oh Y.-M., Shin H., Chang J., Jung J.Y., KOLD Study Group (2020) Low serum lymphocyte level is associated with poor exercise capacity and quality of life in chronic obstructive pulmonary disease. Sci. Rep., 10, 11700. CrossRef Scholar google search
Huang Y., Jiang B., Miao X., Ma J., Wang J., Ding K., Chen X., Hu Q., Fu F., Zeng T., Hu J., Hu B., Yang D., Zhang X. (2020) the relationship of lymphocyte to high-density lipoprotein ratio with pulmonary function in COPD. Int. J. Chron. Obstruct. Pulmon. Dis., 15, 3159–3169. CrossRef Scholar google search
Williams M., Todd I., Fairclough L.C. (2021) The role of CD8+ T lymphocytes in chronic obstructive pulmonary disease: a systematic review. Inflamm. Res., 70(1), 11–18. CrossRef Scholar google search
Ono Y., Fujino N., Saito T., Matsumoto S., Konno S., Endo T., Suzuki M., Yamada M., Okada Y., Sugiura H. (2024) Characterization of IL-6R-expressing monocytes in the lung of patients with chronic obstructive pulmonary disease. Respir. Investig., 62(5), 856–866. CrossRef Scholar google search
Lin C.-H., Li Y.-R., Lin P.R., Wang B.-Y., Lin S.-H., Huang K.-Y., Kor C.-T. (2022) Blood monocyte levels predict the risk of acute exacerbations of chronic obstructive pulmonary disease: a retrospective case-control study. Sci. Rep., 12, 21057. CrossRef Scholar google search
Zahorec R. (2021) Neutrophil-to-lymphocyte ratio, past, present and future perspectives. Bratislava Medical Journal, 122(7), 474–488. CrossRef Scholar google search
Ali A., Abdelhafiz A.S., Saleh M.M., Salem H., Rakha M.A., Ezzat S. (2023) Monocyte to eosinophil ratio as a diagnostic biomarker for overlap syndrome and predictor of disease exacerbation. Int. J. Immunopathol. Pharmacol., 37, 3946320231216321. CrossRef Scholar google search
Gutta L., Ahmed T. (2022) NLR and PLR ratios — accessible and affordable predictors of disease severity in COPD. J. Assoc. Physicians India, 70(4), 11–12. Scholar google search
Liao Q.Q., Mo Y.-J., Zhu K.-W., Gao F., Huang B., Chen P., Jing F.-T., Jiang X., Xu H.-Z., Tang Y.-F., Chu L.-W., Huang H.-L., Wang W.-L., Wei F.-N., Huang D.-D., Zhao B.-J., Chen J., Zhang H. (2024) Platelet-to-lymphocyte ratio (PLR), neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), and eosinophil-tolymphocyte ratio (ELR) as biomarkers in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD). Int. J. Chron. Obstruct. Pulmon. Dis., 19, 501–518. CrossRef Scholar google search
Ling M., Huiyin L., Shanglin C., Haiming L., Zhanyi D., Shuchun W., Meng B., Murong L. (2023) Relationship between human serum albumin and in-hospital mortality in critical care patients with chronic obstructive pulmonary disease. Front. Med., 10, 1109910. CrossRef Scholar google search
Zinellu E., Fois A., Sotgiu E., Mellino S., Mangoni A. (2021) Serum albumin concentrations in stable chronic obstructive pulmonary disease: a systematic review and meta-analysis. J. Clin. Med., 10(2), 269. CrossRef Scholar google search
Mendy A., Forno E., Niyonsenga T., Gasana J. (2018) Blood biomarkers as predictors of long-term mortality in COPD. Clin. Respir. J., 12(5), 1891–1899. CrossRef Scholar google search
Hassan A., Jabbar N. (2022) C-reactive protein as a predictor of severity in chronic obstructive pulmonary disease: an experience from a tertiary care hospital. Cureus, 14(8), e28229. CrossRef Scholar google search
Oshagbemi O., Franssen F., Wouters E., Maitland-van der Zee A., Driessen J., de Boer A., de Vries F. (2020) Creactive protein as a biomarker of response to inhaled corticosteroids among patients with COPD. Pulm. Pharmacol. Ther., 60, 101870. CrossRef Scholar google search
Ben Saad A., Migaou A., Cheikh Mhamed S., Fahem N., Rouatbi N., Joobeur S. (2020) Relationship between CRP levels and the severity of COPD acute exacerbations among group D COPD patients. Eur. Respir. J., 56(Suppl 64), 2443. CrossRef Scholar google search
Banerjee S., Khubchandani J., Onukogu C., Okpom C., Johnson M. (2024) Elevated C-reactive protein and mortality risk among COPD patients. Egypt. J. Bronchol., 18, 38. CrossRef Scholar google search
Fattouh M., Alkady O. (2014) Inflammatory biomarkers in chronic obstructive pulmonary disease. Egypt. J. Chest Dis. Tuberc., 63(4), 799–804. CrossRef Scholar google search
Chen K., Pleasants K.A., Pleasants R.A., Beiko T., Washburn R.G., Yu Z., Zhai S., Drummond M.B. (2020) Procalcitonin for antibiotic prescription in chronic obstructive pulmonary disease exacerbations: systematic review, meta-analysis, and clinical perspective. Pulm. Ther., 6(2), 201–214. CrossRef Scholar google search
Özgür Cırık M., Baldemir R., Doğanay G.E., Ünver M., Avcı S. (2020) The 30-day mortality predictor role of C-reactive protein/albumin ratio in critically ill COPD patients. Crit. Care Innov., 3(4), 1–12. CrossRef Scholar google search
Atalay E., Erdoğdu H.İ., Tur B.K., Deniz Balyen L.S., Karabağ Y., Ardiç S. (2019) The relationship between C reactive protein / albumin ratio and 1-year mortality in hospitalized elderly COPD patients with acute exacerbation. Turkish J. Geriatrics, 22(1), 9–17. CrossRef Scholar google search
Li H., Ma Y., Xue J., He C., Zhan Z., Liu X., Chen P., Cai S., Zeng Y., Wu Q., Chen Y. (2021) C-reactive protein to serum albumin ratio as a novel biomarker to predict prognosis in patients with chronic obstructive pulmonary disease. Clin. Lab., 67(3), DOI: 10.7754/clin.lab.2020.200630. CrossRef Scholar google search
Shen S., Xiao Y. (2023) Association between C-reactive protein and albumin ratios and risk of mortality in patients with chronic obstructive pulmonary disease. Int. J. Chron. Obstruct. Pulmon. Dis., 18, 2289–2303. CrossRef Scholar google search
Таганович А.Д., Ковганко Н.Н., Хотько Е.А., Готько О.В., Прохорова В.И. (2024) Оценка эффективности лечения плоскоклеточного рака легкого на основе определения в крови показателей внутри- и внеклеточного метаболизма. Евразийский Онкологический Журнал, 12(2), 134–150. CrossRef Scholar google search
Gong C., Yang Y., Chen M., Xie Z. (2020) Effect of procalcitonin on the prognosis of patients with COPD. Biomed. Rep., 12(6), 313–318. CrossRef Scholar google search
Restrepo M., Sibila O., Anzueto A. (2018) Pneumonia in patients with chronic obstructive pulmonary disease. Tuberc. Respir. Dis. (Seoul), 81(3), 187–197. CrossRef Scholar google search
Using procalcitonin to guide therapy for acute COPD exacerbations. Retrieved April 9, 2025, from: https://www.jwatch.org/na48613/2019/03/07/usingprocalcitonin- guide-therapy-acute-copd-exacerbations. Scholar google search
Saldías P.F., Díaz P.O., Dreyse D.J., Gaggero B.A., Sandoval A.C., Lisboa B.C. (2011) Etiology and biomarkers of systemic inflammation in mild to moderate COPD exacerbations. Revista medica de Chile, 140, 10–18. CrossRef Scholar google search
Waschki B., Kirsten A., Holz O., Müller K.-C., Meyer T., Watz H., Magnussen H. (2011) Physical activity is the strongest predictor of all-cause mortality in patients with COPD: a prospective cohort study. Chest, 140(2), 331–342. CrossRef Scholar google search
Koutsokera A., Kiropoulos T.S., Nikoulis D.J., Daniil Z.D., Tsolaki V., Tanou K., Papaioannou A.I., Germenis A., Gourgoulianis K.I., Kostikas K. (2009) Clinical, functional and biochemical changes during recovery from COPD exacerbations. Respir. Med., 103(6), 919–926. CrossRef Scholar google search
Teder P., Vandivier R.W., Jiang D., Liang J., Cohn L., Puré E., Henson P.M., Noble P.W. (2002) Resolution of lung inflammation by CD44. Science, 296(5565), 155–158. CrossRef Scholar google search
de Grendele H.C., Kosfiszer M., Estess P., Siegelman M.H. (1997) CD44 activation and associated primary adhesion is inducible via T cell receptor stimulation. J. Immunol., 159(6), 2549–2553. CrossRef Scholar google search
Noguera A., Gomez C., Faner R., Cosio B., González-Périz A., Clària J., Carvajal A., Agustí A. (2012) An investigation of the resolution of inflammation (catabasis) in COPD. Respir. Res., 13(1), 101. CrossRef Scholar google search
Dong Y., Arif A.A., Guo J., Ha Z., Lee-Sayer S.S.M., Poon G.F.T., Dosanjh M., Roskelley C.D., Huan T., Johnson P. (2020) CD44 loss disrupts lung lipid surfactant homeostasis and exacerbates oxidized lipid-induced lung inflammation. Front. Immunol., 11, 29. CrossRef Scholar google search
Heider K.-H., Kuthan H., Stehle G., Munzert G. (2004) CD44v6: a target for antibody-based cancer. Cancer Immunol. Immunother., 53(7), 567–579. CrossRef Scholar google search
Camacho F.I., Muñoz C., Sánchez-Verde L., Sáez A.I., Alcántara M., Rodríguez R. (1999) CD44v6 expression in inflammatory bowel disease is associated with activity detected by endoscopy and pathological features. Histopathology, 35(2), 144–149. CrossRef Scholar google search
Romero-Palacios P.J., Alcázar-Navarrete B., Díaz Mochón J.J., de Miguel-Pérez D., López Hidalgo J.L., Garrido-Navas M.D.C., Quero Valenzuela F., Lorente J.A., Serrano M.J. (2019) Circulating pulmonary cells as biomarkers of COPD aggressivity. Crit. Rev. Oncol. Hematol., 136, 31–36. CrossRef Scholar google search
Fu X., Zhang F. (2018) Role of the HIF-1 signaling pathway in chronic obstructive pulmonary disease. Exp. Ther. Med., 16(6), 4553–4561. CrossRef Scholar google search
Chiş A.F., Soritau O., Catana A., Pop M. (2018) VEGF serum levels in COPD patients without pulmonary hypertension — a case control study. Eur. Respir. J., 52(Suppl 62), PA4071. CrossRef Scholar google search
Rong B., Liu Y., Li M., Fu T., Gao W., Liu H. (2018) Correlation of serum levels of HIF-1α and IL-19 with the disease progression of COPD: a retrospective study. Int. J. Chron. Obstruct. Pulmon. Dis., 13, 3791–3803. CrossRef Scholar google search
Valipour A., Schreder M., Wolzt M., Saliba S., Kapiotis S., Eickhoff P., Burghuber O.C. (2008) Circulating vascular endothelial growth factor and systemic inflammatory markers in patients with stable and exacerbated chronic obstructive pulmonary disease. Clin. Sci. (London), 115(7), 225–232. CrossRef Scholar google search
Hughes C.E, Nibbs R.J.B. (2018) A guide to chemokines and their receptors. FEBS J., 285(16), 2944–2971. CrossRef Scholar google search
Henrot P., Prevel R., Berger P., Dupin I. (2019) Chemokines in COPD: from implication to therapeutic use. Int. J. Mol. Sci., 20(11), 2785. CrossRef Scholar google search
Tangedal S., Aanerud M., Persson L.J.P., Bakke P.S., Eagan T.M.L. (2015) MIG and IP-10 levels in induced sputum of stable and exacerbated COPD patients. Eur. Respir. J., 46(Suppl 59), PA3885. CrossRef Scholar google search
Quint J.K., Donaldson G.C., Goldring J.J.P., Baghai-Ravary R., Hurst J.R., Wedzicha J.A. (2010) Serum IP-10 as a biomarker of human rhinovirus infection at exacerbation of COPD. Chest, 137(4), 812–822. CrossRef Scholar google search
Xue H., Chen Q., Lan X., Xu H., Yang H., Lin C., Xue Q., Xie B. (2024) Preventing CXCL12 elevation helps to reduce acute exacerbation of COPD in individuals co-existing type-2 diabetes: a bioinformatics and clinical pharmacology study. Int. Immunopharmacol., 132, 111894. CrossRef Scholar google search
Stuart M.J., Baune B.T. (2014) Chemokines and chemokine receptors in mood disorders, schizophrenia, and cognitive impairment: a systematic review of biomarker studies. Neurosci. Biobehav. Rev., 42, 93–115. CrossRef Scholar google search
Mukaida N. (2003) Pathophysiological roles of interleukin-8/CXCL8 in pulmonary diseases. Am. J. Physiol. Lung Cell. Mol. Physiol., 284(4), 566–577. CrossRef Scholar google search
Kim V., Cornwell W.D., Oros M., Durra H., Criner G.J., Rogers T.J. (2015) Plasma chemokine signature correlates with lung goblet cell hyperplasia in smokers with and without chronic obstructive pulmonary disease. BMC Pulm. Med., 15, 111. CrossRef Scholar google search
Zarcone M.C., Duistermaat E., Alblas M.J., van Schadewijk A., Ninaber D.K., Clarijs V., Moerman M.M., Vaessen D., Hiemstra P.S., Kooter I.M. (2018) Effect of diesel exhaust generated by a city bus engine on stress responses and innate immunity in primary bronchial epithelial cell cultures. Toxicol. In Vitro, 48, 221–231. CrossRef Scholar google search
Reutershan J., Morris M.A., Burcin T.L., Smith D.F., Chang D., Saprito M.S., Ley K. (2006) Critical role of endothelial CXCR2 in LPS-induced neutrophil migration into the lung. J. Clin. Invest., 116(3), 695–702. CrossRef Scholar google search
Zhang J., Bai C. (2018) The significance of serum interleukin-8 in acute exacerbations of chronic obstructive pulmonary disease. Tanaffos, 17(1), 13–21. Scholar google search
Kuźnar-Kamińska B., Mikuła-Pietrasik J., Witucka A., Romaniuk A., Konieczna N., Rubiś B., Książek K., Tykarski A., Batura-Gabryel H. (2018) Serum from patients with chronic obstructive pulmonary disease induces senescence-related phenotype in bronchial epithelial cells. Sci. Rep., 8, 12940. CrossRef Scholar google search
Pignatti P., Moscato G., Casarini S., Delmastro M., Poppa M., Brunetti G., Pisati P., Balbi B. (2005) Downmodulation of CXCL8/IL-8 receptors on neutrophils after recruitment in the airways. J. Allergy Clin. Immunol., 115(1), 88–94. CrossRef Scholar google search
Аaron S.D., Angel J.B., Lunau M., Wright K., Fex C., le Saux N., Dales R.E. (2001) Granulocyte inflammatory markers and airway infection during acute exacerbation of chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med., 163(2), 349–355. CrossRef Scholar google search
Han M.K., Quibrera P.M., Carretta E.E., Barr R.G., Bleecker E.R., Bowler R.P., Cooper C.B., Comellas A., Couper D.J., Curtis J.L., Criner G., Dransfield M.T., Hansel N.N., Hoffman E.A., Kanner R.E., Krishnan J.A., Martinez C.H., Pirozzi C.B., O'Neal W.K., Rennard S., Tashkin D.P., Wedzicha J.A., Woodruff P., Paine R. 3rd, Martinez F.J. (2017) Frequency of exacerbations in patients with chronic obstructive pulmonary disease: an analysis of the SPIROMICS cohort. Lancet Respir. Med., 5(8), 619–626. CrossRef Scholar google search
Wuyts A., d’Haese A., Cremers V., Menten P., Lenaerts J.P., de Loof A., Heremans H., Proost P., van Damme J. (1999) NH2- and COOH-terminal truncations of murine granulocyte chemotactic protein-2 augment the in vitro and in vivo neutrophil chemotactic potency. J. Immunol., 163(11), 6155–6163. CrossRef Scholar google search
Tanino M., Betsuyaku T., Takeyabu K., Tanino Y., Yamaguchi E., Miyamoto K., Nishimura M. (2002) Increased levels of interleukin-8 in BAL fluid from smokers susceptible to pulmonary emphysema. Thorax, 57(5), 405–411. CrossRef Scholar google search
Qiu Y., Zhu J., Bandi V., Atmar R.L., Hattotuwa K., Guntupalli K.K., Jeffery P.K. (2003) Biopsy neutrophilia, neutrophil chemokine and receptor gene expression in severe exacerbations of chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med., 168(8), 968–975. CrossRef Scholar google search
Chen J., Dai L., Wang T., He J., Wang Y., Wen F. (2019) The elevated CXCL5 levels in circulation are associated with lung function decline in COPD patients and cigarette smoking-induced mouse model of COPD. Ann. Med., 51(5–6), 314–329. CrossRef Scholar google search
Nie L., Liu Z.-J., Zhou W.-X., Xiang R.-L., Xiao Y., Lu B., Pang B.-S., Gao J.-M. (2010) Chemokine receptor CXCR3 is important for lung tissue damage and airway remodeling induced by short-term exposure to cigarette smoking in mice. Acta Pharmacol. Sin., 31(4), 436–442. CrossRef Scholar google search
Tahanovich A., Kadushkin A. (2017) Chemokine receptor CXCR3 expression on naive and memory B-lymphocytes of patients with COPD. Eur. Respir. J., 50(Suppl 61), PA2025. CrossRef Scholar google search
Xue M.-Q., Liu J., Sang J.-F., Su L., Yao Y.-Z. (2017) Expression characteristic of CXCR1 in different breast tissues and the relevance between its expression and efficacy of neo-adjuvant chemotherapy in breast cancer. Oncotarget, 8(30), 48930–48937. CrossRef Scholar google search
Dupin I., Henrot P., Maurat E., Abohalaka R., Chaigne S., El Hamrani D., Eyraud E., Prevel R., Esteves P., Campagnac M., Dubreuil M., Cardouat G., Bouchet C., Ousova O., Dupuy J.-W., Trian T., Thumerel M., Begueret H., Girodet P.-O., Marthan R., Zysman M., Freund-Michel V., Berger P. (2025) CXCR4 blockade alleviates pulmonary and cardiac outcomes in early COPD. Am. J. Respir. Cell Mol. Biol., DOI: 10.1165/rcmb.2024-0303OC. Epub ahead of print. CrossRef Scholar google search
Duplin I., Dubreuil M., Freund-Michel V., Maurat E., Campagnac M., Ousova O., Trian T., Girodet P.-O., Berger P. (2019) Targeting CXCR4 as a therapeutic strategy to improve outcomes in a mouse model of early chronic obstructive pulmonary disease (COPD). ERJ Open Res., 5(Suppl 2), PP225. CrossRef Scholar google search
Nasser M.W., Raghuwanshi S.K., Grant D.J., Jala V.R., Rajarathnam K., Richardson R.M. (2009) Differential activation and regulation of CXCR1 and CXCR2 by CXCL8 monomer and dimer. J. Immunol., 183(5), 3425–3432. CrossRef Scholar google search
Schulz C., Stoelcker B., Ruhland B., Jentsch N., Steege A. (2012) Bronchoepithelial expression of CXCR1 and CXCR2 does not facilitate transepithelial migration of neutrophils. Respiration, 84(2), 108–116. CrossRef Scholar google search
Fahimi F., Alam M.J., Ang C., Adhyatma G.P., Xie L., Mackay C.R., Robert R. (2023) Human CXCR1 knock-in mice infer functional expression of a murine ortholog. J. Leukoc. Biol., 114(4), 373–380. CrossRef Scholar google search
Yamagata T., Sugiura H., Yokoyama T., Yanagisawa S., Ichikawa T., Ueshima K., Akamatsu K., Hirano T., Nakanishi M., Yamagata Y., Matsunaga K., Minakata Y., Ichinose M. (2007) Overexpression of CD-11b and CXCR1 on circulating neutrophils: its possible role in COPD. Chest, 132(3), 890–899. CrossRef Scholar google search
Stockley J., Peat L., Walton G., Lord J., Sapey E. (2014) The role of chemokine receptors in the aberrant migration of COPD neutrophils. Eur. Respir. J., 44(Suppl 58), P3859. CrossRef Scholar google search
Yang M., Xu D., Liu Y., Guo X., Li W., Guo C., Zhang H., Gao Y., Mao Y., Zhao J. (2022) Combined serum biomarkers in non-invasive diagnosis of non-alcoholic steatohepatitis. PLOS One, 10(6), e0131664. CrossRef Scholar google search
