Проанализированы масс-спектрометрические данные, полученные при анализе тканей гиппокампа пациентов склеротической и несклеротической височной эпилепсии и без неё для выявления различий в уровне посттрансляционных модификаций (ПТМ) белков. Исходные протеомные данные, полученные Mathoux и соавт. [DOI: 10.1172/jci.insight.188612], были депонированы в репозитории PRIDE (идентификатор PXD064519). В результате сравнительного протеомного анализа образцов отобрано 53 белка с ПТМ (фосфорилирование, метилирование, ацетилирование и цитруллинирование), имеющих существенные изменения в уровне отдельных модифицированных пептидов. Согласно литературным данным, все 53 белка вовлечены в процессы, связанные с неврологическими заболеваниями в целом или эпилептогенезом в частности. Проведённый анализ позволил выявить ПТМ белков, которые могут играть важную роль в патогенезе развития неврологических заболеваний.
Мирошниченко Ю.В., Рыбина А.В., Скворцов В.С. (2025) Идентификация белков с меняющимся уровнем посттрансляционных модификаций при височной эпилепсии у человека. Биомедицинская химия, 71(5), 351-363.
Мирошниченко Ю.В. и др. Идентификация белков с меняющимся уровнем посттрансляционных модификаций при височной эпилепсии у человека // Биомедицинская химия. - 2025. - Т. 71. -N 5. - С. 351-363.
Мирошниченко Ю.В. и др., "Идентификация белков с меняющимся уровнем посттрансляционных модификаций при височной эпилепсии у человека." Биомедицинская химия 71.5 (2025): 351-363.
Мирошниченко, Ю. В., Рыбина, А. В., Скворцов, В. С. (2025). Идентификация белков с меняющимся уровнем посттрансляционных модификаций при височной эпилепсии у человека. Биомедицинская химия, 71(5), 351-363.
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