Эпидемиологические исследования показывают, что во всём мире, в том числе в РФ, наблюдается устойчивый рост числа пациентов с когнитивными нарушениями, связанными с нейродегенеративными заболеваниями и различными аффективными расстройствами. В связи с этим существует запрос на разработку более действенных терапевтических подходов к их коррекции. Установлено, что регулярная физическая нагрузка способствует улучшению когнитивных функций и подавляет симптомы депрессии. Работающие мышцы секретируют биологически активные вещества — миокины, регулирующие восстановление самих мышц, а также регулирующие функции внутренних органов, желёз внутренней секреции, иммунной системы и мозга. Результатом является скоординированный ответ органов и систем, направленный на восстановление функциональной активности организма после физической нагрузки. В частности, улучшается память и способность к обучению. Пациенты с когнитивными нарушениями или депрессией часто не способны вовлечься в регулярную физическую активность из-за физических ограничений или ослабления мотивации. В связи с этим фармацевтические препараты, имитирующие эффекты мышечной активности, являются перспективной терапевтической опцией. Одним из направлений может стать создание препаратов на основе миокина иризина, который вырабатывается во время физической нагрузки и оказывает целый ряд благотворных эффектов на когнитивные функции и настроение. В этом обзоре представлены данные по влиянию физической нагрузки на когнитивные функции в норме и при патологии, описано физиологическое действие иризина, представлены предполагаемые механизмы действия иризина на когнитивные функции и симптомы депрессии.
Гисина А.М., Ярыгин К.Н. (2025) Миокин иризин: воздействие на головной мозг и терапевтический потенциал в лечении депрессии и нейродегенеративных заболеваний. Биомедицинская химия, 71(6), 379-399.
Гисина А.М. и др. Миокин иризин: воздействие на головной мозг и терапевтический потенциал в лечении депрессии и нейродегенеративных заболеваний // Биомедицинская химия. - 2025. - Т. 71. -N 6. - С. 379-399.
Гисина А.М. и др., "Миокин иризин: воздействие на головной мозг и терапевтический потенциал в лечении депрессии и нейродегенеративных заболеваний." Биомедицинская химия 71.6 (2025): 379-399.
Гисина, А. М., Ярыгин, К. Н. (2025). Миокин иризин: воздействие на головной мозг и терапевтический потенциал в лечении депрессии и нейродегенеративных заболеваний. Биомедицинская химия, 71(6), 379-399.
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