Мультиформная глиобластома (ГБМ) — наиболее агрессивная первичная опухоль головного мозга, характеризующаяся крайне неблагоприятным прогнозом. Трудности в диагностике и мониторинге данного заболевания создают необходимость поиска минимально инвазивных подходов, среди которых перспективным направлением считается жидкостная биопсия. Данный обзор посвящен анализу результатов современных исследований, направленных на поиск циркулирующих белковых биомаркеров ГБМ в плазме и сыворотке крови. В качестве биомаркеров рассматриваются свободно циркулирующие белки плазмы крови и белки, находящиеся в составе внеклеточных везикул (ВнВ). В обзоре обобщены результаты работ, использующих для поиска белковых биомаркеров как иммунохимические методы, так и масс-спектрометрические подходы, а также представлен перечень выявленных потенциальных диагностических и прогностических биомаркеров. Анализ представленных в литературе работ показывает, что протеомный анализ, сосредоточенный на фракции ВнВ плазмы крови, существенно расширяет возможности поиска биомаркеров для неинвазивной диагностики и мониторинга ГБМ.
Майоров В.А. и др. Циркулирующие белковые биомаркеры глиобластомы: методологические подходы и перспективы развития // Биомедицинская химия. - 2025. - Т. 71. -N 6. - С. .
Майоров В.А. и др., "Циркулирующие белковые биомаркеры глиобластомы: методологические подходы и перспективы развития." Биомедицинская химия 71.6 (2025): .
Майоров, В. А., Тихонова, О. В., Згода, В. Г. (2025). Циркулирующие белковые биомаркеры глиобластомы: методологические подходы и перспективы развития. Биомедицинская химия, 71(6), .
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