Получены результаты, показывающие кардиопротекторное действие природного антиоксиданта астаксантина (АСТ) на митохондрии сердца крыс при хронической алкогольной интоксикации. В частности, АСТ восстанавливал дыхательную активность и Ca2+-ёмкость митохондрий сердца при хронической алкогольной интоксикации, оказывал положительное влияние на баланс функционально-значимых процессов деления/слияния митохондрий, а также митофагии. Кроме того, АСТ предотвращал морфологические повреждения ткани сердца, вызванные алкоголем. В целом, результаты показывают, что АСТ способствует нормализации работы митохондрий сердца, защищая их от дегенеративных изменений, вызванных алкогольной интоксикацией, и улучшая энергетический метаболизм сердечной ткани. Таким образом, астаксантин помогает компенсировать повреждения митохондрий сердца, вызванные хроническим приёмом алкоголя, восстанавливая их функциональную активность и устойчивость к стрессу.
Крестинина О.В. и др. Астаксантин защищает митохондрии сердца от повреждений, вызванных хронической алкогольной интоксикацией // Биомедицинская химия. - 2026. - Т. 72. -N 1. - С. 28-41.
Крестинина О.В. и др., "Астаксантин защищает митохондрии сердца от повреждений, вызванных хронической алкогольной интоксикацией." Биомедицинская химия 72.1 (2026): 28-41.
Крестинина, О. В., Одинокова, И. В., Звягина, А. И., Сотников, Р. Р., Сотникова, Л. Д., Бабурина, Ю. Л. (2026). Астаксантин защищает митохондрии сердца от повреждений, вызванных хронической алкогольной интоксикацией. Биомедицинская химия, 72(1), 28-41.
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