Unlike other cytochrome P450-dependent oxygenase inhibitors, ketoconazole has been shown to suppress the murine macrophage-mediated oxidative modification of human low-density lipoproteins (LDL) in a dose-dependent manner. The benzo[alpha]pyrene-induced microsomal monooxygenase activity was accomplished by a 1,5-fold increase in LDL oxidation by macrophages, ketokonazole (20 mu), methoxalene (20 mu), and alpha-naphthaflavone (50 mu). Ketoconazole was also effective in inhibiting macrophageal NADPH oxidase and LDL autooxidation induced by Fe2+ rather than Cu+, which is likely to be associated with its ability to act as a chelator of free and heme-bound iron ions.
Download PDF:
Citation:
Dushkin M.I., Zenkov N.K., Pivovarova E.N., Lyubimov G.Yu., Menshikova Ye.B. (1996) Effects of cytochrome P-450 inhibitors on macrophage-induced oxidative modification of low density Lipoproteins. Voprosy Meditsinskoi Khimii, 42(1), 23-30.
Dushkin M.I. et al. Effects of cytochrome P-450 inhibitors on macrophage-induced oxidative modification of low density Lipoproteins // Voprosy Meditsinskoi Khimii. - 1996. - V. 42. -N 1. - P. 23-30.
Dushkin M.I. et al., "Effects of cytochrome P-450 inhibitors on macrophage-induced oxidative modification of low density Lipoproteins." Voprosy Meditsinskoi Khimii 42.1 (1996): 23-30.
Dushkin, M. I., Zenkov, N. K., Pivovarova, E. N., Lyubimov, G. Yu., Menshikova, Ye. B. (1996). Effects of cytochrome P-450 inhibitors on macrophage-induced oxidative modification of low density Lipoproteins. Voprosy Meditsinskoi Khimii, 42(1), 23-30.
References
Душкин М.И., Мандрикова Е.В., Любимов Г.И. и др. // Биохимия — 1990. — Т. 55, вып. 9. - С . 1607-1615. Scholar google search
Душкин М.И., Корнюш Е.А., Поляков Л.М. и др. // Там же — 1992. — Т. 57, вып. 8 —С 1181-1191. Scholar google search
Душкин М.И., Зыков А.А., Пивоварова Е.В. // Бюл. экспер. биол. — 1993. — N 10. —С. 393-395. Scholar google search
Зенков Н.К., Меньшикова Е.Б. // Успехи соврем, биол. — 1993. — Т. 113, вып. 3. —С. 286-296. Scholar google search
Зенков Н.К., Душкин М.И., Любимов Г.Ю., Меньщикова Е.Б. // Вопр мед. химии. — 1994- т. 40, N 1. — С 2-4. Scholar google search
Современные методы в биохимии / Под ред. В.Н Ореховича. — М., 1977 —С. 248-253. Scholar google search
Aasen Т.В., Bolann В., Glette J. et аl. // Scand J. din. Lab. Invest. — 1987. - Vol 30. —P 673-681. Scholar google search
