Heart maintains a gradient for creatine under physiological conditions, so that creatine release is relatively small. Calcium depletion, addition of strophanthin or decrease of sodium concentration (till 80 mM) provoke release of creatine. Elevation of transmembrane sodium gradient by raising of extracellular sodium concentration prevented loss of creatine. The effect of elevated concentration of sodium ions was blocked by strophanthin but depended on osmolarity, because solutions with the same osmolarity that hypersodium media had no protective effect on release of creatine. A sarcolemmal mechanism of Na creatine cotransports is proposed.
Alabovsky V.V., Winokurov A.A. (1996) Effect of transmembrane sodium gradient on myocardial creatine release. Voprosy Meditsinskoi Khimii, 42(4), 291-295.
Alabovsky V.V. et al. Effect of transmembrane sodium gradient on myocardial creatine release // Voprosy Meditsinskoi Khimii. - 1996. - V. 42. -N 4. - P. 291-295.
Alabovsky V.V. et al., "Effect of transmembrane sodium gradient on myocardial creatine release." Voprosy Meditsinskoi Khimii 42.4 (1996): 291-295.
Alabovsky, V. V., Winokurov, A. A. (1996). Effect of transmembrane sodium gradient on myocardial creatine release. Voprosy Meditsinskoi Khimii, 42(4), 291-295.
References
Henberg G., Klockner U. // Pfluger's Arch. - 1982. - V 395. - P. 6-18. Scholar google search
Chapman R.A., Tunstall J. // Progr. Physiol. Mol. Biol. — 1987. — V. 50. — P. 67-96. Scholar google search
Винокуров A A. / Значение трансмембранного фадиента натрия в осуществлении защитного действия макроэргических соединений при повреждении сердца ионами кальция Автореф. дис. канд. мед. наук Смоленск 1992.-С 23. Scholar google search
Suleiman M.S., Rodrigo G.C., Chapman R.A. // Cardiovasc. Res. — 1992. - V. 267. — P. 897-905. Scholar google search
Eggleton P., Elsden S.R., Cough N. // Biochem. J. - 1943. - V. 37. - P . 526-529. Scholar google search
Кужман M.M., Алабовский B.B., Олейников О.Д. // Веста. АМН СССР. —1984 — N 8. С 35-41. Scholar google search
Bhojani I.H., Chapman R.A. // J Mol. Cell. Cardiol - 1990. - V 22. - P. 507-522. Scholar google search
Lamers J.M.J, Stinis J. Т., Ruigrok T.J.C. // Circ. Res. - 1984 - V. 54. - N 2 . - P . 217-226. Scholar google search
