Pattern of rat liver histones at intensive physical exercises with preliminary injection of lysosomotropic drugs was studied by method of electrophoresis in PAAG. Elevation of the acetylated forms of histone H4 was revealed. The increased proteolysis of lysine-rich histones (H1, H2A, H2B) was shown in swimming rats previously stimulated by prodigiosan. The possible role of lysosomal proteinases of liver cells in mechanism of chromatine activation is discussed.
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Keywords: histones, stress, proteolysis, prodigiosan, rat liver, chrroloquine
Citation:
Panin L.E., Svechnikova I.G., Mayanskaya N.N. (1996) Charging in histone protein pattern of rat liver chromatine under organism functional stress conditions. Voprosy Meditsinskoi Khimii, 42(4), 295-300.
Panin L.E. et al. Charging in histone protein pattern of rat liver chromatine under organism functional stress conditions // Voprosy Meditsinskoi Khimii. - 1996. - V. 42. -N 4. - P. 295-300.
Panin L.E. et al., "Charging in histone protein pattern of rat liver chromatine under organism functional stress conditions." Voprosy Meditsinskoi Khimii 42.4 (1996): 295-300.
Panin, L. E., Svechnikova, I. G., Mayanskaya, N. N. (1996). Charging in histone protein pattern of rat liver chromatine under organism functional stress conditions. Voprosy Meditsinskoi Khimii, 42(4), 295-300.
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